Document Detail

Glyceryl trinitrate but not spontaneous NO donors preserve myocardial function and cell integrity in ischemic rabbit hearts.
MedLine Citation:
PMID:  7717178     Owner:  NLM     Status:  MEDLINE    
Langendorff-perfused rabbit hearts were subjected to 2 h of global, low-flow ischemia followed by 30 min of reperfusion. This resulted in a marked increase of left ventricular enddiastolic pressure and a loss in left ventricular creatine phosphokinase activity. NO formation was significantly reduced in early reperfusion. In the presence of superoxide dismutase (20 U/ml), NO release (oxyhemoglobin technique) was completely normalized, indicating inactivation of NO by superoxide radicals. Treatment with glyceryl trinitrate (GTN; 30 microM) prevented ischemia-induced myocardial tissue injury. SIN-1 (0.3 microM) was ineffective. These data demonstrate a protective effect of GTN but not SIN-1 in myocardial ischemia. It is concluded that the site of NO generation may play an important role in determining the biological activity of NO donating substances.
I Woditsch; K Schrör
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Agents and actions. Supplements     Volume:  45     ISSN:  0379-0363     ISO Abbreviation:  Agents Actions Suppl.     Publication Date:  1995  
Date Detail:
Created Date:  1995-05-18     Completed Date:  1995-05-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7801014     Medline TA:  Agents Actions Suppl     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  189-94     Citation Subset:  IM    
Institut für Pharmakologie, Heinrich-Heine-Universität Düsseldorf, FRG.
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MeSH Terms
Creatine Kinase / drug effects,  metabolism
Molsidomine / analogs & derivatives*,  pharmacology
Myocardial Reperfusion Injury / metabolism,  physiopathology*,  prevention & control
Myocardium / cytology,  metabolism*
Nitric Oxide / metabolism*
Nitroglycerin / pharmacology*
Superoxide Dismutase / pharmacology*
Reg. No./Substance:
10102-43-9/Nitric Oxide; 25717-80-0/Molsidomine; 33876-97-0/3-morpholino-sydnonimine; 55-63-0/Nitroglycerin; EC Dismutase; EC Kinase

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