Document Detail

Glycerophosphate-dependent hydrogen peroxide production by rat liver mitochondria.
MedLine Citation:
PMID:  15209538     Owner:  NLM     Status:  MEDLINE    
We studied the extent to which hormonally-induced mitochondrial glycerophosphate dehydrogenase (mGPDH) activity contributes to the supply of reducing equivalents to the mitochondrial respiratory chain in the rat liver. The activity of glycerophosphate oxidase was compared with those of NADH oxidase and/or succinate oxidase. It was found that triiodothyronine-activated mGPDH represents almost the same capacity for the saturation of the respiratory chain as Complex II. Furthermore, the increase of mGPDH activity induced by triiodothyronine correlated with an increase of capacity for glycerophosphate-dependent hydrogen peroxide production. As a result of hormonal treatment, a 3-fold increase in glycerophosphate-dependent hydrogen peroxide production by liver mitochondria was detected by polarographic and luminometric measurements.
P Jesina; D Kholová; R Bolehovská; Z Cervinková; Z Drahota; J Houstek
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  53     ISSN:  0862-8408     ISO Abbreviation:  Physiol Res     Publication Date:  2004  
Date Detail:
Created Date:  2004-06-22     Completed Date:  2005-01-11     Revised Date:  2008-04-02    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  305-10     Citation Subset:  IM    
Center for Integrated Genomics, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
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MeSH Terms
Ferricyanides / pharmacology*
Glycerolphosphate Dehydrogenase / drug effects,  metabolism*
Glycerophosphates / metabolism*
Hydrogen Peroxide / metabolism*
Mitochondria, Liver / drug effects,  metabolism*
Oxygen / metabolism*
Rats, Wistar
Triiodothyronine / pharmacology*
Reg. No./Substance:
0/Ferricyanides; 0/Glycerophosphates; 13408-62-3/hexacyanoferrate III; 6893-02-3/Triiodothyronine; 7722-84-1/Hydrogen Peroxide; 7782-44-7/Oxygen; EC 1.1.-/Glycerolphosphate Dehydrogenase

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