Document Detail

Glycerol reduces food intake in diabetic rats.
MedLine Citation:
PMID:  6757988     Owner:  NLM     Status:  MEDLINE    
Streptozotocin diabetic rats received four daily subcutaneous injections of glycerol or a glycerol solution in place of water for a seven day period. Both night and total food intake in the subcutaneous glycerol group were significantly suppressed below untreated diabetic controls. The oral glycerol group showed a nonsignificant decrease in night foot intake and a significant reduction in day and total food intake. Consumption of additional fluid calories by the oral glycerol group contributed to the suppression of food intake in this group, but suppression in the subcutaneous group was unrelated to calculated calories obtained from glycerol. The oral glycerol group also consumed more of the glycerol solution than the other diabetic groups did of water. Results of this study support previous findings that subcutaneous and oral glycerol suppress food intake in normal rats although suppression with oral glycerol may have related to caloric intake, and suggest that low plasma concentrations of insulin do not interfere with the effects obtained with glycerol in normal animals.
D J Brief; J D Davis
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Physiology & behavior     Volume:  29     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1983-02-14     Completed Date:  1983-02-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  577-80     Citation Subset:  IM    
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MeSH Terms
Body Weight / drug effects
Diabetes Mellitus, Experimental / blood*
Drinking / drug effects
Eating / drug effects*
Energy Intake / drug effects
Glycerol / pharmacology*
Insulin / blood
Grant Support
Reg. No./Substance:
11061-68-0/Insulin; 56-81-5/Glycerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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