Document Detail


Glycerol reduces food intake in diabetic rats.
MedLine Citation:
PMID:  6757988     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Streptozotocin diabetic rats received four daily subcutaneous injections of glycerol or a glycerol solution in place of water for a seven day period. Both night and total food intake in the subcutaneous glycerol group were significantly suppressed below untreated diabetic controls. The oral glycerol group showed a nonsignificant decrease in night foot intake and a significant reduction in day and total food intake. Consumption of additional fluid calories by the oral glycerol group contributed to the suppression of food intake in this group, but suppression in the subcutaneous group was unrelated to calculated calories obtained from glycerol. The oral glycerol group also consumed more of the glycerol solution than the other diabetic groups did of water. Results of this study support previous findings that subcutaneous and oral glycerol suppress food intake in normal rats although suppression with oral glycerol may have related to caloric intake, and suggest that low plasma concentrations of insulin do not interfere with the effects obtained with glycerol in normal animals.
Authors:
D J Brief; J D Davis
Related Documents :
1881988 - The effects of pregnancy and lactation on dietary self-selection in the rat.
19043208 - Fluvoxamine inhibits weight gain and food intake in food restricted hyperphagic wistar ...
6214808 - Effect of insulin and 2-deoxy-d-glucose on the food intake of infant rats.
2628998 - Effects of time of feeding on recovery of food-entrained rhythms during subsequent fast...
17952418 - Surfactant to dye binding degree based approach for the selective determination of l-gl...
3989288 - On the establishing of permissible relations between macc- and mact-values of harmful s...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Physiology & behavior     Volume:  29     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1983-02-14     Completed Date:  1983-02-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  577-80     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / drug effects
Diabetes Mellitus, Experimental / blood*
Drinking / drug effects
Eating / drug effects*
Energy Intake / drug effects
Glycerol / pharmacology*
Insulin / blood
Male
Rats
Grant Support
ID/Acronym/Agency:
AM 26030/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
11061-68-0/Insulin; 56-81-5/Glycerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Metabolic and physiologic effects of a hunger-inducing injection of insulin.
Next Document:  Celiac vagotomy attenuates the ingestive responses to epinephrine and hypertonic saline but not insu...