Document Detail


Glycerol loss to water exceeds glycerol catabolism via glycerol kinase in freeze resistant rainbow smelt (Osmerus mordax).
MedLine Citation:
PMID:  21178128     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Rainbow smelt accumulate high amounts of glycerol in winter to remain active in freezing waters. In smelt, there is a predictable profile of plasma glycerol levels that starts to increase in November (< 5 μmoles.ml(-1)), peaks in mid-February (> 200 μmoles.ml(-1)) and thereafter decreases to reach the initial levels in the beginning of May. The aim of this study was to investigate the respective role of the two main mechanisms that might be involved in glycerol clearance from mid-February: 1) breakdown of glycerol to glycerol-3-phosphate through the action of the glycerol kinase (GK) and 2) direct loss toward the environment. Over the entire glycerol cycle, loss to water represents a daily loss of about 10% of the total glycerol content of fish. GK activities were very low in all tissues investigated and likely have a minor quantitative role in the glycerol cycle. These results suggest that glycerol levels are dictated by the rate of glycerol synthesis (accelerated and deactivated during the accumulation and decrease stages, respectively). Although not important in glycerol clearance, GK in liver might have an important metabolic function for other purposes such as gluconeogenesis, as evidenced by the significant increase of activity at the end of the cycle.
Authors:
Delphine Ditlecadet; Connie Elizabeth Short; William R Driedzic
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-22
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  -     ISSN:  1522-1490     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Ocean Sciences Centre/Memorial university of Newfoundland.
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