Document Detail

Glycerokinase in mammalian adipose tissue: stimulation by lipogenic substances.
MedLine Citation:
PMID:  168785     Owner:  NLM     Status:  MEDLINE    
A connecting link between carbohydrate and fat metabolism in adipose tissue is theconcentration of alpha-glycerophosphate derived predominantly from the glycolysis ofglucose entering the fat cell. However, several investigators have reported the presence of a glycerol specific kinase in the epidiymal fat-pad of the rat and obob mouse. This enzyme's presence in other mammalian adipose tissue could contribute to the alpha-glycerophosphate pool and thus affect both carbohydrate and fat metabolism within the fat cell. Glycerokinase was demonstrated in isolated fat cells obtained from the subcutaneous, perirenal, epididymal, and dorsal intrascapular brown fat depots of the adultmale rat. It was found to be particularly sensitive to in vivo lipogenic stimuli in both the subcutaneous and the brown adipose tissue and concluded that insulin is involved in adipose glycerokinase stimulation. Therefore, the main function of glycerokinase in normal adipose tissue may be to augment the anabolic action of insulin. It isfurther suggested that deviation from the normal control of this lipogenic enzyme couldlead to a gradual accumulation of fat and eventual obesity.
P A Persico; M Cerchio; H Jeffay
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  228     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1975 Jun 
Date Detail:
Created Date:  1975-11-08     Completed Date:  1975-11-08     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1868-74     Citation Subset:  IM    
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MeSH Terms
Adipose Tissue / enzymology*
Adipose Tissue, Brown / metabolism
Arginine / pharmacology
Glucose / pharmacology
Glycerol / pharmacology
Glycerol Kinase / metabolism*
Insulin / pharmacology
Phosphotransferases / metabolism*
Stimulation, Chemical
Reg. No./Substance:
11061-68-0/Insulin; 50-99-7/Glucose; 56-81-5/Glycerol; 74-79-3/Arginine; EC 2.7.-/Phosphotransferases; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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