Document Detail


Glycerogenic pathway in the rat mammary gland.
MedLine Citation:
PMID:  3569649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The conversions of the isotope from [1-14C]acetate, [1-14C]glucose and [6-14C]glucose to CO2 and fatty acids in acini isolated from the mammary gland at the peak of lactation were studied. The incorporation of [9,10-3H]oleate into triacylglycerol synthesis as single substrate or in combination with substrates that potentially may supply trioses-phosphate was also determined. The rate of fatty acid synthesis paralleled the activity of the hexose monophosphate shunt and the data obtained reveal that little carbon from triose stage enters the phosphohexose pool via reversal of glycolytic pathway. The results are interpreted in terms of the NADPH producing systems and phosphoenolpyruvate carboxykinase activities as well as the possible implications in lipogenic and glyceroneogenic pathways.
Authors:
J Jiménez; A Page-Peñuelas; M Ros; J P García-Ruíz; F J Moreno
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The International journal of biochemistry     Volume:  19     ISSN:  0020-711X     ISO Abbreviation:  Int. J. Biochem.     Publication Date:  1987  
Date Detail:
Created Date:  1987-06-15     Completed Date:  1987-06-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0250365     Medline TA:  Int J Biochem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  201-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetates / metabolism
Animals
Fatty Acids / biosynthesis
Female
Glucose / metabolism
Glycerol / biosynthesis*
Glycerophosphates / biosynthesis
Lactation / metabolism*
Mammary Glands, Animal / metabolism*
Oleic Acid
Oleic Acids / metabolism
Pregnancy
Rats
Rats, Inbred Strains
Triglycerides / biosynthesis
Chemical
Reg. No./Substance:
0/Acetates; 0/Fatty Acids; 0/Glycerophosphates; 0/Oleic Acids; 0/Triglycerides; 112-80-1/Oleic Acid; 50-99-7/Glucose; 56-81-5/Glycerol; 57-03-4/alpha-glycerophosphoric acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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