| Glycemic optimization may reduce lipid peroxidation independent of weight and blood lipid changes in Type 2 diabetes mellitus. | |
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MedLine Citation:
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PMID: 16295049 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to determine the effect of diet-therapy on lipid peroxidation in patients with Type 2 diabetes mellitus (T2DM). Fifteen T2DM patients of both sexes, aged between 35-70 years, were given the diet suggested for patients with diabetes by the American Diabetic Association. This diet comprised 50-60% carbohydrate, 10-15% protein, 20-30% fat and about 35 g fiber was given for weight maintenance. Weight and body mass index did not change significantly during 8 weeks of study. Also, no statistically significant difference was observed in serum total cholesterol, triglycerides, LDL- and HDL-cholesterol from before to after dietary intervention. However, the levels of fasting blood sugar, HbA1c and malondialdehyde were lowered significantly after dietary intervention. It was concluded that glycemic optimization, independent of weight and blood lipid profile, through a well-designed diet is likely to be the most effective factor in reducing the process of oxidative stress in T2DM. This may have preventive implications for such diabetic complications as atherosclerosis. |
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Authors:
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T R Neyestani; R Alipour-Birgani; F Siassi; M Rajayi; M Djalali; M Mohamadi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Diabetes, nutrition & metabolism Volume: 17 ISSN: 0394-3402 ISO Abbreviation: Diabetes Nutr. Metab. Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2005-11-18 Completed Date: 2005-12-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8813443 Medline TA: Diabetes Nutr Metab Country: Italy |
Other Details:
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Languages: eng Pagination: 275-9 Citation Subset: IM |
Affiliation:
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Laboratory of Nutrition Research, National Institute of Nutrition Research and Food Technology, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. tneyestani@nnftri.ac.ir |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Atherosclerosis / prevention & control Blood Glucose / metabolism* Body Mass Index Body Weight Diabetes Mellitus, Type 2 / blood, diet therapy*, metabolism Diabetic Angiopathies / prevention & control Diabetic Diet* Female Hemoglobin A, Glycosylated / metabolism Humans Lipid Peroxidation* Lipids / blood Male Malondialdehyde / blood Middle Aged Oxidative Stress |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 0/Lipids; 542-78-9/Malondialdehyde |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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