Document Detail

Glycemic control and perinatal outcomes of pregnancies complicated by type 1 diabetes: influence of continuous subcutaneous insulin infusion and lispro insulin.
MedLine Citation:
PMID:  21128840     Owner:  NLM     Status:  MEDLINE    
AIMS: This study compared glycemic control and maternal and fetal outcomes in pregnant women with type 1 diabetes mellitus (T1DM) treated with multiple daily injections (MDI) or continuous subcutaneous insulin infusion (CSII) using regular (RI) or lispro (LP) insulin.
METHODS: Three hundred fifteen consecutive singleton pregnancies of T1DM women using the same insulin program since before pregnancy (196 MDI with NPH + RI, 16 MDI with NPH + LP, 44 CSII with RI, 59 CSII with LP) were studied. Variables of glycemic control assessed included glycated hemoglobin, mean blood glucose (MBG), and insulin doses in each trimester, diabetic ketoacidosis, and hypoglycemic comas. Variables of pregnancy outcome included miscarriage, preterm birth, large or small for gestational age (LGA or SGA, respectively) newborns, and perinatal mortality. Multiple linear regression and logistic regression analysis were used.
RESULTS: Groups differed in baseline and glycemic control but not in maternal or fetal outcomes. In multivariate analysis, LP was associated with higher second trimester MBG and lower rate of hypoglycemic coma, CSII with higher third trimester MBG, and CSII + LP with lower insulin requirements and lower rate of hypoglycemic coma. As to pregnancy outcomes, LP was associated with lower risk of preterm birth and higher risk of SGA, CSII with lower risk of SGA and higher risk of LGA and perinatal mortality, and CSII + LP with higher risk of miscarriage.
CONCLUSIONS: Pregnant women with T1DM using LP and/or CSII had different characteristics. LP with or without CSII was independently associated with fewer hypoglycemic comas, whereas impact of LP/CSII on the fetus had a favorable or an unfavorable influence depending on the specific outcome.
Ana Chico; Ignasi Saigi; Apolonia García-Patterson; M Dolores Santos; Juan M Adelantado; Gemma Ginovart; Alberto de Leiva; Rosa Corcoy
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetes technology & therapeutics     Volume:  12     ISSN:  1557-8593     ISO Abbreviation:  Diabetes Technol. Ther.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-06     Completed Date:  2011-04-08     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  100889084     Medline TA:  Diabetes Technol Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  937-45     Citation Subset:  IM    
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MeSH Terms
Blood Glucose / metabolism
Cohort Studies
Diabetes Mellitus, Type 1 / blood*,  drug therapy*
Hemoglobin A, Glycosylated / metabolism
Hypoglycemia / blood
Hypoglycemic Agents / administration & dosage*
Infant, Newborn
Infusion Pumps, Implantable
Insulin / administration & dosage,  analogs & derivatives*
Insulin Infusion Systems*
Insulin Lispro
Pregnancy Outcome
Pregnancy in Diabetics / blood*,  drug therapy*
Regression Analysis
Reg. No./Substance:
0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 0/Hypoglycemic Agents; 0/Insulin; 0/Insulin Lispro

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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