| Glycemia and inflammatory markers in acute coronary syndrome: association with late post-hospital outcomes. | |
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MedLine Citation:
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PMID: 17478004 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Glycemia and inflammatory markers were associated with clinical outcomes in patients with acute coronary syndrome (ACS). OBJECTIVES: To evaluate the role of glycemia and inflammatory markers as predictors of late cardiovascular outcomes after ACS. METHODS: One hundred and ninety-nine ACS patients of a Coronary Care Unit were included, from March to November 2002. They were reassessed clinically after approximately 3 years. Clinical variables, glycemia, CRP and fibrinogen were evaluated as event and mortality predictors. Statistical analyses included Cox multivariate analysis and survival curves (Kaplan-Meier). RESULTS: At admission, 16.7% had normal glycemia. After 3 years, this proportion increased to 55.2%; the 40.6% who belonged to the borderline category decreased to 27.1%; the 42.7% with elevated glycemia decreased to 17.7%. Glycemia was not associated with the development of major cardiovascular events (MACE) and mortality at follow-up ( approximately 3 years). Considering MACE, CRP (p<0.001), but not fibrinogen, was predictive in bivariate analysis. Regarding mortality, both fibrinogen (p=0.020) and CRP (p=0.008) were predictive in bivariate analysis. CONCLUSION: Glycemia was not associated with late mortality after ACS, but inflammatory markers were, suggesting that these are more sensitive markers to predict events in long-term. Moreover, glucose intolerance prevalence is lower in the follow-up after the ACS episode. |
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Authors:
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Patrícia Tolledo Maciel; Lucia Campos Pellanda; Vera Lucia Portal; Beatriz D'Agord Schaan |
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Publication Detail:
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Type: Journal Article Date: 2007-05-02 |
Journal Detail:
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Title: Diabetes research and clinical practice Volume: 78 ISSN: 0168-8227 ISO Abbreviation: Diabetes Res. Clin. Pract. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-01 Completed Date: 2007-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8508335 Medline TA: Diabetes Res Clin Pract Country: Ireland |
Other Details:
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Languages: eng Pagination: 263-9 Citation Subset: IM |
Affiliation:
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Institute of Cardiology of Rio Grande do Sul, University Foundation of Cardiology, Porto Alegre, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Coronary Syndrome
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diagnosis*,
mortality Aged Biological Markers / analysis* Blood Glucose / metabolism* C-Reactive Protein / analysis Female Fibrinogen / analysis Humans Inflammation / diagnosis* Male Middle Aged Prognosis |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Blood Glucose; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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