Document Detail


Glycemia in newborns of hypertensive mothers according to maternal treatment.
MedLine Citation:
PMID:  15543394     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To evaluate the evolution of glycemic levels in newborns of hypertensive mothers according to maternal treatment. METHODS: Prospective randomized study, including 93 newborns of mothers treated with isradipine (n = 39), atenolol (n = 40), or low sodium diet (control group - n=14). Glycemia was determined at birth (mother and newborn by the oxidase glucose method) and in the 1st, 3rd, 6th, 12th, and 24th hours after birth (newborn by a test strip method). The evolution of glycemia was analyzed in each group (Friedman test). The groups were compared regarding glycemia (Kruskall-Wallis test), and linear regression models were constructed for the analyses (independent variable = maternal glycemia; dependent variables = umbilical cord, 3rd, and 6th hour glycemia). RESULTS: There were no statistically significant differences among the mean blood glucose levels of the 3 groups in any of the assessments. There was a correlation between maternal and umbilical cord blood glucose in the isradipine (r = 0.61; P <.05) and control (r = 0.84; P <.05) groups. Regarding glycemia levels of the mothers and newborns in the third and sixth hours postpartum, this correlation was present only in the control group (maternal x third hour: r = 0.65; P <.05; maternal x sixth hour: r = 0.68; P <.05). There were no correlations in the atenolol group. Hypoglycemia was detected in 51.3% of the isradipine group, 60% of the atenolol group, and 35.7% of the control group, and it was more frequent in the first hour postpartum in all groups. CONCLUSIONS: The results suggest a similar effect of the 3 types of treatment upon newborn glycemia. The correlation analysis suggests that isradipine could have effects upon newborn glycemia only after birth (correlation only in umbilical cord blood), whereas atenolol could act earlier (there was no correlation at any moment). The results also point to the need for glycemic control from the first hour postpartum of newborns of hypertensive mothers whether they have or have not undergone treatment with antihypertensive drugs.
Authors:
Silvana Darcie; Cléa R Leone; Valdenise M L T Calil; Elizete P Prescinotti; Soubhi Kahhale; Marcelo Zugaib
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2004-10-29
Journal Detail:
Title:  Revista do Hospital das Clínicas     Volume:  59     ISSN:  0041-8781     ISO Abbreviation:  Rev Hosp Clin Fac Med Sao Paulo     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-11-15     Completed Date:  2006-10-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0415246     Medline TA:  Rev Hosp Clin Fac Med Sao Paulo     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  244-50     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil. sdarcie@uol.com.br
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MeSH Terms
Descriptor/Qualifier:
Antihypertensive Agents / therapeutic use*
Apgar Score
Atenolol / therapeutic use
Blood Glucose / analysis,  drug effects*
Epidemiologic Methods
Female
Fetal Blood / chemistry
Humans
Hypertension / blood,  drug therapy*
Infant, Newborn
Isradipine / therapeutic use*
Pregnancy
Pregnancy Complications, Cardiovascular / blood,  drug therapy*
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Blood Glucose; 29122-68-7/Atenolol; 75695-93-1/Isradipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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