| Glycemia and immunohistochemical changes in the endocrine pancreas of the turtle Chrysemys dorbigni treated with streptozotocin. | |
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MedLine Citation:
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PMID: 2534475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The diabetogenic action of streptozotocin (SZ) was investigated in the turtle Chrysemys dorbigni after a 1- or 14-day fast. SZ (130 or 250 mg/kg) was injected intravenously, and blood glucose and plasma insulin were measured. Pancreatic endocrine cells were stained immunohistochemically by the immunoperoxidase avidin-biotin-peroxidase complex method. Only 14% of the SZ-treated turtles showed hyperglycemia. Prolonged fasting did not increase the percentage of hyperglycemic animals. In control turtles, insulin (beta)-, glucagon (alpha)- and somatostatin (delta)-immunoreactive cells were detected in increasing order of frequency. The qualitative changes seen in cells from the hyperglycemic SZ-treated turtles were more evident in beta and delta cells. |
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Authors:
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W W Muniz; M Marques |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] Volume: 22 ISSN: 0100-879X ISO Abbreviation: Braz. J. Med. Biol. Res. Publication Date: 1989 |
Date Detail:
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Created Date: 1990-05-29 Completed Date: 1990-05-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8112917 Medline TA: Braz J Med Biol Res Country: BRAZIL |
Other Details:
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Languages: eng Pagination: 1033-7 Citation Subset: IM |
Affiliation:
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Departamento de Patologia, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / analysis* Fasting Female Immunohistochemistry Insulin / blood* Islets of Langerhans / drug effects*, pathology Male Streptozocin / pharmacology* Turtles / blood* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 11061-68-0/Insulin; 18883-66-4/Streptozocin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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