Document Detail

Glycated hemoglobin in fractionated erythrocytes.
MedLine Citation:
PMID:  2731368     Owner:  NLM     Status:  MEDLINE    
Erythrocytes were fractionated, by centrifugation, on the basis of cell density, which is proportional to cell age. Glycated hemoglobin (Hb A1c) in the fractionated cells was measured and compared with the Hb A1c in whole blood and with the fructosamine concentrations in plasma of normal and diabetic subjects. In normal subjects, Hb A1c increased according to the age of the erythrocytes, but hyperbolically rather than linearly, indicating the slow conversion of Hb A to Hb A1c with saturability. The greatest correlation of Hb A1c with plasma fructosamine was in younger middle-aged cells. A subgroup of subjects with impaired glucose tolerance had high Hb A1c in older cells. Hb A1c of the young cells reflects recent glycemic status, for monitoring the initial stage of the treatment of diabetics, whereas Hb A1c of the older middle-aged cells more specifically reflects the longer term glycemic status, for screening and for the long-term monitoring index for treatment of diabetes.
K Nakashima; O Nishizaki; Y Andoh; H Takei; A Itai; Y Yoshida
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical chemistry     Volume:  35     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-07-21     Completed Date:  1989-07-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  958-62     Citation Subset:  IM    
Department of Laboratory Medicine, St. Luke's College of Nursing, Tokyo, Japan.
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MeSH Terms
Cell Separation
Diabetes Mellitus / blood,  diagnosis
Erythrocyte Aging
Erythrocytes / analysis*,  enzymology
Hemoglobin A, Glycosylated / analysis*
Hexosamines / blood
Middle Aged
Pyruvate Kinase / metabolism
Serum Albumin / analysis
Reg. No./Substance:
0/Hemoglobin A, Glycosylated; 0/Hexosamines; 0/Serum Albumin; 0/glycosylated serum albumin; 4429-04-3/Fructosamine; EC Kinase

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