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Glycated albumin is independently associated with estimated glomerular filtration rate in nondiabetic patients with chronic kidney disease.
MedLine Citation:
PMID:  21172335     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Glycated albumin (GA) may contribute to diabetic nephropathy, but the clinical significance of GA in patients with chronic kidney disease (CKD) is unknown. METHODS: Patients were classified with the NKF/DOQI classification system as mild (stage I, II), moderate (stage III), or advanced CKD (stage IV). Those undergoing dialysis or with CKD stage V were excluded. GA was measured using the Lucica TM GA-L assay kit. The relationship between GA and renal dysfunction was analyzed in patients with or without diabetes. RESULTS: A total of 187 subjects were enrolled. GA values in those with normal, mild, moderate and advanced CKD were 18.4±1.4%, 18.4±3.1%, 19.0±3.8%, 20.4±6.4%, respectively, in diabetic patients (N=67, p=0.5), and were 14.1±1.9%, 14.2±2.2%, 15.9±1.9%, 15.0±1.7%, respectively, in nondiabetic patients (N=120, p=0.004). GA value was negatively correlated to eGFR in nondiabetic patients (r=-0.35, p<0.001) but not in diabetic patients (r=-0.11, p=0.39). In the adjusted model, GA is independently correlated to eGFR only in nondiabetic subjects. CONCLUSIONS: Increased GA concentrations are independently associated with renal dysfunction in nondiabetic patients with CKD.
Authors:
Wen-Ya Ma; Chia-Chao Wu; Dee Pei; Kuo-Chin Hung; Te-Lin Hsia; Ching-Chieh Su; Yi-Min Chu; Kuo-Cheng Lu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-21
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  -     ISSN:  1873-3492     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2011-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Affiliation:
Department of Internal Medicine, Cardinal Tien Hospital, Medical School, Catholic Fu Jen University, Taiwan.
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