Document Detail


Glycan-specific metabolic oligosaccharide engineering of c7-substituted sialic acids.
MedLine Citation:
PMID:  22674889     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
A new sialic acid in the house! A biosynthetic approach gives access to previously inaccessible C7 modifications of sialic acids in living cells. Metabolic incorporation of synthetically derived N-acetyl-4-azido-4-deoxymannosamine into glycans of mammalian cells and zebrafish larvae preserves the bioorthogonal functionality of its azido group for subsequent labeling with biophysical probes.
Authors:
Heinz Möller; Verena Böhrsch; Joachim Bentrop; Judith Bender; Stephan Hinderlich; Christian P R Hackenberger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Angewandte Chemie (International ed. in English)     Volume:  51     ISSN:  1521-3773     ISO Abbreviation:  Angew. Chem. Int. Ed. Engl.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370543     Medline TA:  Angew Chem Int Ed Engl     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  5986-90     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Beuth Hochschule für Technik Berlin-University of Applied Sciences, Department of Life Sciences and Technology, Seestrasse 64, 13347 Berlin (Germany).
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