Document Detail

Glycan-Specific Metabolic Oligosaccharide Engineering of C7-Substituted Sialic Acids.
MedLine Citation:
PMID:  22644729     Owner:  NLM     Status:  Publisher    
A biosynthetic method using a synthetic C4-modified mannosamine derivative provides the previously inaccessible C7 modifications of sialic acids in living cells. S. Hinderlich, C. P. R. Hackenberger, and co-workers also show in their Communication (10.1002/anie.201108809) that their synthetic mannosamine derivative could label the membrane-associated glycoproteins of live animals. The picture shows the "machinery" which converts the new mannosamine compound into sialic acid and transports it to glycoproteins on the cell surface. (© O'Reilly Science Art).
Heinz Möller; Verena Böhrsch; Joachim Bentrop; Judith Bender; Stephan Hinderlich; Christian P R Hackenberger
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-29
Journal Detail:
Title:  Angewandte Chemie (International ed. in English)     Volume:  -     ISSN:  1521-3773     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370543     Medline TA:  Angew Chem Int Ed Engl     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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