| 'Glycaemic variability': a new therapeutic challenge in diabetes and the critical care setting. | |
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MedLine Citation:
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PMID: 20653741 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Much attention has been paid recently to the possibility that oscillating glucose may superimpose on glycated haemoglobin (HbA(1c)) in determining the risk for diabetes complications. Furthermore, recent evidence suggests that glucose variability, particularly if accompanied by frequent hypoglycaemic episodes, may adversely alter the prognosis of acutely ill patients. In vitro and animal studies confirm that oscillating glucose is more dangerous than stable constant high glucose, particularly in activating the pathways involved in the pathogenesis of diabetes complications. The production of free radicals, accompanied by an insufficient increase in intracellular antioxidant defences, seems to account for this phenomenon. In humans, studies also confirm that fluctuating glucose levels produce an increase in free radicals as well as endothelial dysfunction, and that these changes are greater than those produced by stable high glucose. Avoiding glucose fluctuations in diabetic patients and in critically ill patients seems to be an emerging therapeutic challenge. |
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Authors:
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A Ceriello; M A Ihnat |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Diabetic medicine : a journal of the British Diabetic Association Volume: 27 ISSN: 1464-5491 ISO Abbreviation: Diabet. Med. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8500858 Medline TA: Diabet Med Country: England |
Other Details:
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Languages: eng Pagination: 862-7 Citation Subset: IM |
Affiliation:
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Insititut d'Investigacions Biomédiques August Pi i Sunyer, Barcelona, Spain. aceriell@clinic.ub.es |
Export Citation:
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Descriptor/Qualifier:
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| Comments/Corrections | |
Comment In:
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Diabet Med. 2010 Aug;27(8):868-71
[PMID:
20653742
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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