| Glycaemic variability is associated with coronary artery calcium in men with Type 1 diabetes: the Coronary Artery Calcification in Type 1 Diabetes study. | |
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MedLine Citation:
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PMID: 21059097 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: We investigated coronary artery calcium in association with glucose levels and variability measured using continuous glucose monitoring in adults with Type 1 diabetes in the Coronary Artery Calcification in Type 1 Diabetes study. METHODS: Coronary artery calcium was measured by electron beam tomography. The presence of any coronary artery calcium was analysed with respect to glucose levels [mean(T) (mean glucose), % of values < 3.9 mmol/l, > 10 mmol/l and either < 3.9 or > 10 mmol/l] and glycaemic variability [sd(T) (sd of all glucose values); sd(dm) (sd of the daily mean glucose levels) and sd(hh:mm) (glucose sd for a specified time of day, over all days)] using 3-5 days of continuous glucose monitoring from 75 subjects (45 women, 30 men), age 42 ± 9 years (mean ± sd) and diabetes duration of 29 ± 8 years using logistic regression. RESULTS: We observed significant associations between coronary artery calcium and mean(T) (OR = 4.4, 95% CI 1.1-18.6), % of values > 10 mmol/l (OR = 5.5, 95% CI 1.3-22.6), % of measures < 3.9 or > 10 mmol/l (OR = 5.7, 95% CI 1.3-24.9), sd(T) (OR = 4.7, 95% CI 1.1-19.7), sd(dm) (OR = 6.0, 95% CI 1.2-30.4) and sd(hh:mm) (OR = 4.0, 95% CI 1.1-15.4), among men, but none of these variables were associated with the presence of coronary artery calcium in women. CONCLUSIONS: We report the novel finding that subclinical atherosclerosis is associated with glucose levels and variability in men with Type 1 diabetes. The relationship of coronary artery calcium and glucose variability in Type 1 diabetes, and potential gender differences in this association, deserve further study. |
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Authors:
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J K Snell-Bergeon; R Roman; D Rodbard; S Garg; D M Maahs; I E Schauer; B C Bergman; G L Kinney; M Rewers |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Diabetic medicine : a journal of the British Diabetic Association Volume: 27 ISSN: 1464-5491 ISO Abbreviation: Diabet. Med. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-09 Completed Date: 2011-03-28 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 8500858 Medline TA: Diabet Med Country: England |
Other Details:
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Languages: eng Pagination: 1436-42 Citation Subset: IM |
Copyright Information:
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© 2010 The Authors. Diabetic Medicine © 2010 Diabetes UK. |
Affiliation:
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Barbara Davis Center for Childhood Diabetes, School of Medicine, University of Colorado Denver, Aurora, CO, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Glucose / analysis* Calcium / metabolism* Coronary Artery Disease / blood, etiology, pathology* Coronary Vessels / metabolism* Diabetes Mellitus, Type 1 / blood*, complications Diabetic Angiopathies / blood, complications, pathology* Female Hemoglobin A, Glycosylated / analysis Humans Male Risk Factors Sex Distribution Tomography, X-Ray Computed |
| Grant Support | |
ID/Acronym/Agency:
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HL61753/HL/NHLBI NIH HHS; M01 RR000051/RR/NCRR NIH HHS; M01 RR000051-431195/RR/NCRR NIH HHS; P30 DK57516/DK/NIDDK NIH HHS; R01 HL061753-01/HL/NHLBI NIH HHS; R01 HL079611/HL/NHLBI NIH HHS; R01 HL079611-01/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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