| Glycaemic control and incidence of heart failure in 20,985 patients with type 1 diabetes: an observational study. | |
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MedLine Citation:
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PMID: 21705065 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Poor glycaemic control is associated with microvascular and macrovascular complications in type 1 diabetes, but whether glycaemic control is associated with heart failure in such patients is not known. We aimed to assess this association in a large cohort of patients with type 1 diabetes identified from the Swedish national diabetes registry. METHODS: We identified all patients (aged ≥18 years) with type 1 diabetes and no known heart failure who were registered in the national diabetes registry between January, 1998, and December, 2003. These patients were followed up until hospital admission for heart failure, death, or end of follow-up on Dec 31, 2009. We calculated incidence categorised by glycated haemoglobin A(1c) (HbA(1c)) values, and we assessed the association between patients' characteristics, including HbA(1c), and heart failure. FINDINGS: In a cohort of 20,985 patients with mean age of 38·6 years (SD 13·3) at baseline, 635 patients (3%) were admitted to hospital with a primary or secondary diagnosis of heart failure during a median follow-up of 9·0 years (IQR 7·3-11·0), with an incidence of 3·38 events per 1000 patient-years (95% CI 3·12-3·65). Incidence increased monotonically with HbA(1c), with a range of 1·42-5·20 per 1000 patient-years between patients in the lowest (<6·5%) and highest (≥10·5%) categories of HbA(1c). In a Cox regression analysis, with adjustment for age, sex, duration of diabetes, cardiovascular risk factors, and baseline or intervening acute myocardial infarction and other comorbidities, the hazard ratio for development of heart failure was 3·98 (95% CI 2·23-7·14) in patients with HbA(1c) of 10·5% or higher compared with a reference group of patients with HbA(1c) of less than 6·5%. Risk of heart failure increased with age and duration of diabetes. Other modifiable factors associated with increased risk of heart failure were smoking, high systolic blood pressure, and raised body-mass index. In a subgroup of 18,281 patients (87%) with data for blood lipids, higher HDL cholesterol was associated with lower risk of heart failure, but there was no association with LDL cholesterol. INTERPRETATION: The positive association between HbA(1c) and risk of heart failure in fairly young patients with type 1 diabetes indicates a potential for prevention of heart failure with improved glycaemic control. FUNDING: AstraZeneca, Novo Nordisk Scandinavia, Swedish Heart and Lung Foundation, and Swedish Research Council. |
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Authors:
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Marcus Lind; Ioannis Bounias; Marita Olsson; Soffia Gudbjörnsdottir; Ann-Marie Svensson; Annika Rosengren |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-06-24 |
Journal Detail:
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Title: Lancet Volume: 378 ISSN: 1474-547X ISO Abbreviation: Lancet Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-07-11 Completed Date: 2011-08-23 Revised Date: 2011-10-03 |
Medline Journal Info:
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Nlm Unique ID: 2985213R Medline TA: Lancet Country: England |
Other Details:
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Languages: eng Pagination: 140-6 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. lind.marcus@telia.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cholesterol, HDL / blood Cholesterol, LDL / blood Diabetes Mellitus, Type 1 / epidemiology* Diabetic Angiopathies / epidemiology* Female Heart Failure / epidemiology* Hemoglobin A, Glycosylated / analysis Humans Incidence Male Middle Aged Proportional Hazards Models Sweden / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Hemoglobin A, Glycosylated |
| Comments/Corrections | |
Comment In:
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Nat Rev Endocrinol. 2011;7(9):497
[PMID:
21769115
]
Lancet. 2011 Jul 9;378(9786):103-4 [PMID: 21705067 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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