| Glyburide prevents isoflurane's reducing effects on hydroxyl radical formation in the postischemic reperfused rat heart. | |
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MedLine Citation:
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PMID: 19644575 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: The role of K(ATP) channels in isoflurane's reducing effects on oxygen free radical formation are not well known. OBJECTIVES: To investigate whether glyburide, an ATP-regulated potassium (K(ATP)) channel blocker, abolishes isoflurane-induced cardioprotective effects and whether it affects hydroxyl radical formation in the postischemic reperfused heart. ANIMALS AND METHODS: Thirty-nine male Wistar rats were divided into four groups: group C (control, n=10), group I (isoflurane, n=9), group G (glyburide, n=10) and group GI (glyburide and isoflurane, n=10). The hearts were perfused as a Neely's working heart model. Afterwards, global heart ischemia was induced for 15 min followed by reperfusion for 20 min. The formation of hydroxyl radicals in the coronary effluent and heart was measured with high performance liquid chromatography. RESULTS: Isoflurane alone and glyburide alone produced significant decreases in the duration of ventricular fibrillation during reperfusion (group C 452+/-345, group I 247+/-60, group G 261+/-135 s; P<0.05). In the presence of glyburide, isoflurane did not further decrease the duration of arrhythmia (group GI 230+/-48 s). Isoflurane reduced hydroxyl radical formation significantly in the coronary effluent during ischemia and reperfusion, but this was prevented by glyburide. CONCLUSION: The results suggest that isoflurane reduces hydroxyl radical formation, at least in part, through activation of K(ATP) channels. |
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Authors:
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Toshiaki Yamaguchi; Satoshi Kashimoto; Takeshi Oguchi; Teruo Kumazawa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Experimental and clinical cardiology Volume: 7 ISSN: 1205-6626 ISO Abbreviation: Exp Clin Cardiol Publication Date: 2002 |
Date Detail:
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Created Date: 2009-07-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9715903 Medline TA: Exp Clin Cardiol Country: Canada |
Other Details:
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Languages: eng Pagination: 25-9 Citation Subset: - |
Affiliation:
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Department of Anesthesiology, Yamanashi Medical University, Yamanashi, Japan. |
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