| Gluteofemoral Adipose Tissue Plays a Major Role in Production of the Lipokine Palmitoleate in Humans. | |
| | |
MedLine Citation:
|
PMID: 22492525 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The expansion of lower-body adipose tissue (AT) is paradoxically associated with reduced cardiovascular disease and diabetes risk. We examined whether the beneficial metabolic properties of lower-body AT are related to the production and release of the insulin-sensitizing lipokine palmitoleate (16:1n-7). Using venoarterial difference sampling, we investigated the relative release of 16:1n-7 from lower-body (gluteofemoral) and upper-body (abdominal subcutaneous) AT depots. Paired gluteofemoral and abdominal subcutaneous AT samples were analyzed for triglyceride fatty acid composition and mRNA expression. Finally, the triglyceride fatty acid composition of isolated human preadipocytes was determined. Relative release of 16:1n-7 was markedly higher from gluteofemoral AT compared with abdominal subcutaneous AT. Stearoyl-CoA desaturase 1 (SCD1), the key enzyme involved in endogenous 16:1n-7 production, was more highly expressed in gluteofemoral AT and was associated with greater enrichment of 16:1n-7. Furthermore, isolated human preadipocytes from gluteofemoral AT displayed a higher content of SCD1-derived fatty acids. We demonstrate that human gluteofemoral AT plays a major role in determining systemic concentrations of the lipokine palmitoleate. Moreover, this appears to be an inherent feature of gluteofemoral AT. We propose that the beneficial metabolic properties of lower-body AT may be partly explained by the intrinsically greater production and release of palmitoleate. |
| | |
Authors:
|
Katherine E Pinnick; Matt J Neville; Barbara A Fielding; Keith N Frayn; Fredrik Karpe; Leanne Hodson |
Related Documents
:
|
489255 - Studies on peptides. lxxxi. application of a new arginine derivative, ng-mesitylene-2-s... 4966825 - Presence and function of sulur-containing transfer ribonucleic acid of bacillus subtilis. 8407105 - New method for the synthesis of n-methyl amino acids containing peptides by reductive m... 10424345 - In situ generation of fmoc-amino acid chlorides using bis-(trichloromethyl) carbonate a... 16139275 - Effect of 4-hydroxynonenal on phosphatidylethanolamine containing condensed monolayer a... 9303215 - Effect of maternal dietary n-3 fatty acids on the accretion of long-chain polyunsaturat... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-4-9 |
Journal Detail:
|
Title: Diabetes Volume: - ISSN: 1939-327X ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
|
Created Date: 2012-4-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372763 Medline TA: Diabetes Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Oxford, U.K. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cellular Responses to the Metal-Binding Properties of Metformin.
Next Document: Transient Receptor Potential Vanilloid Type 1-Dependent Regulation of Liver-Related Neurons in the P...