| Gluten sensitivity and neuromyelitis optica: two case reports. | |
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MedLine Citation:
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PMID: 15965221 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neuromyelitis optica is a clinical syndrome characterised by acute transverse myelitis plus an acute or subacute optic neuritis with or without recovery. Although once believed to be a variant of multiple sclerosis, diagnostic criteria have recently been proposed for neuromyelitis optica, making it a clinically distinct syndrome. The term gluten sensitivity refers to a state of heightened immunological responsiveness to ingested gluten in genetically susceptible individuals, as indicated by circulating antibodies to gliadin. Several neurological complications have been described associated with gluten sensitivity ranging from peripheral neuropathy and cerebellar ataxia to an increased risk of epilepsy. Although myelopathy has been described in some case reports of coeliac disease, neuromyelitis optica has never been described in association with gluten sensitivity. We describe two cases of gluten sensitivity presenting as neuromyelitis optica with no previous history of significant gastrointestinal symptoms. Gluten sensitivity was confirmed by immunological and histological studies. |
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Authors:
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S Jacob; M Zarei; A Kenton; H Allroggen |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of neurology, neurosurgery, and psychiatry Volume: 76 ISSN: 0022-3050 ISO Abbreviation: J. Neurol. Neurosurg. Psychiatr. Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-06-20 Completed Date: 2005-07-19 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 2985191R Medline TA: J Neurol Neurosurg Psychiatry Country: England |
Other Details:
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Languages: eng Pagination: 1028-30 Citation Subset: IM |
Affiliation:
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Department of Neurology, University Hospitals of Leicester NHS Trust, Royal Infirmary, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antibodies / blood Celiac Disease / diagnosis*, immunology, pathology Diagnosis, Differential Dominance, Cerebral / physiology Female Glutens / immunology Humans Magnetic Resonance Imaging Myelitis, Transverse / diagnosis, immunology, pathology Neurologic Examination Neuromyelitis Optica / diagnosis*, immunology, pathology Optic Nerve / immunology, pathology Spinal Cord / immunology, pathology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 8002-80-0/Glutens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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