Document Detail


Glutathione status in the blood and tissues of patients with virus-originated hepatocellular carcinoma.
MedLine Citation:
PMID:  17706189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Glutathione status can be regarded as the redox status for many diseases. This study was performed to investigate the glutathione status in virus-originated hepatocellular carcinoma (HCC). DESIGN AND METHODS: The blood and tissue samples were obtained from 24 patients. Blood samples were also obtained from 137 controls for comparison. RESULTS: The GSH level and the ratios of GSH/GSSG and GSH/total glutathione of the blood samples from the patients were significantly lower than those of the controls, while the GSSG values were significantly higher. Meanwhile, levels of GSH and total glutathione, as well as the ratios of GSH/GSSH and GSH/total glutathione, were significantly decreased, whereas GSSG levels were significantly higher, in the HCC tissues than those of the adjacent cancer-free tissues. CONCLUSIONS: Glutathione status in the HCC suggested that the antioxidant system is severely impaired, supporting a consistent role of the free radical cytotoxicity in the pathophysiology of the disease.
Authors:
King-Teh Lee; Shih-Meng Tsai; Shen-Nien Wang; Shu-Kai Lin; Szu-Hwa Wu; Shih-Chung Chuang; Szu-Hsien Wu; Hsu Ma; Li-Yu Tsai
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Publication Detail:
Type:  Journal Article     Date:  2007-07-05
Journal Detail:
Title:  Clinical biochemistry     Volume:  40     ISSN:  0009-9120     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-07     Completed Date:  2007-12-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1157-62     Citation Subset:  IM    
Affiliation:
Division of Hepatobiliary Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Carcinoma, Hepatocellular / blood*,  etiology,  pathology,  virology
Case-Control Studies
Female
Glutathione / blood*,  metabolism*
Glutathione Disulfide / analysis,  blood
Hepatitis Viruses
Hepatitis, Viral, Human / complications*
Humans
Liver Neoplasms / blood*,  etiology,  pathology,  virology
Male
Middle Aged
Chemical
Reg. No./Substance:
27025-41-8/Glutathione Disulfide; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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