Document Detail


Glutathione s-transferase gene polymorphisms in Italian patients with sudden sensorineural hearing loss.
MedLine Citation:
PMID:  16788422     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HYPOTHESIS: To investigate the association between glutathione S-transferase (GST) gene polymorphisms and sudden sensorineural hearing loss (SSNHL) in a population of consecutive Italian patients. Assuming that reactive oxygen species formation may play a role in inner ear damage, we investigated whether profiles of GSTs antioxidant enzymes M1 and T1 genotypes may be associated with the risk of SSNHL. STUDY DESIGN: A prospective study in patients with SSNHL. PATIENTS AND METHODS: We investigated 80 Italian patients with SSNHL for the frequency of GSTT1 and GSTM1 polymorphisms. Genotype distribution of all factors found in patients were compared with those of 80 healthy control subjects of the same ethnic background using chi and odds-ratio analysis. Statistical significance was accepted at a level of p < 0.05. RESULTS: In our series, the frequencies of GSTM1 and GSTT1 null genotypes did not differ from those of the control subjects. CONCLUSION: The few studies regarding genetic polymorphisms of GSTs in SSNHL are not conclusive. Further studies are needed to investigate the role of antioxidants including GSTs in SSNHL and to provide the lacking information to improve our knowledge in the field before implementing the use of genetic polymorphism in the SSNHL medicine daily practice.
Authors:
Gabriella Cadoni; Stefania Boccia; Simona Scipione; Dario Arzani; Francesco Cianfagna; Gualteiro Ricciardi; Gaetamo Paludetti; Stefania Agostino
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology     Volume:  27     ISSN:  1531-7129     ISO Abbreviation:  Otol. Neurotol.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-28     Completed Date:  2008-05-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100961504     Medline TA:  Otol Neurotol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1166-9     Citation Subset:  IM    
Affiliation:
Institute of Otorhinolaryngology, Catholic University of the Sacred Heart, Rome, Italy. gab.cad@tiscali.it
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Case-Control Studies
Chi-Square Distribution
Female
Gene Deletion
Glutathione Transferase / genetics*
Hearing Loss, Sensorineural / genetics*
Hearing Loss, Sudden / genetics*
Humans
Male
Middle Aged
Polymerase Chain Reaction
Polymorphism, Genetic*
Prospective Studies
Chemical
Reg. No./Substance:
EC 2.5.1.18/Glutathione Transferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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