Document Detail

Glutathione reverses systemic hemodynamic changes induced by acute hyperglycemia in healthy subjects.
MedLine Citation:
PMID:  7611393     Owner:  NLM     Status:  MEDLINE    
The present study aimed at evaluating whether acute elevations of plasma glucose concentrations could influence systemic hemodynamic parameters and baroreflex activity in humans. Plasma glucose concentrations were acutely raised to 15 mmol/l in 12 healthy male volunteers. During hyperglycemia, there were significant increments of systolic [from 118 +/- 9 to 138 +/- 12 (SD) mmHg, P < 0.01] and diastolic (from 71 +/- 5 to 85 +/- 6 mmHg, P < 0.001) blood pressure, as well as heart rate (from 76 +/- 7 to 85 +/- 10 beats/min, P < 0.01) and plasma catecholamine levels. Both maximal and steady-state mean arterial pressure after squatting were higher during hyperglycemia (27 +/- 8 and 16 +/- 6 mmHg, respectively) compared with levels obtained during euglycemia (18 +/- 5 and 2 +/- 0.6 mmHg, respectively, P < 0.001). The infusion of the somatostatin analogue octreotide (25 micrograms as i.v. bolus followed by a 0.5 microgram/min infusion), to avoid the possible confounding vascular actions of insulin, did not influence the hemodynamic effects of hyperglycemia except for a lesser increase of both heart rate and plasma catecholamines. Glutathione (600 mg as an iv bolus followed by a 5 mg/min infusion) completely prevented the vascular effects of hyperglycemia. This study shows that acute hyperglycemia, similar to that observed in poorly controlled diabetic patients, produces relevant systemic hemodynamic changes and also alters baroreflex activity via a glutathione-sensitive presumably free radical-mediated pathway.
R Marfella; G Verrazzo; R Acampora; C La Marca; R Giunta; C Lucarelli; G Paolisso; A Ceriello; D Giugliano
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  268     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-08-15     Completed Date:  1995-08-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E1167-73     Citation Subset:  IM    
Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy.
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MeSH Terms
Baroreflex / drug effects,  physiology*
Blood Glucose / metabolism*
Diastole / drug effects
Glucose Clamp Technique
Glutathione / pharmacology*
Heart Rate / drug effects
Hemodynamics / drug effects,  physiology*
Hyperglycemia / physiopathology*
Insulin / blood
Octreotide / pharmacology*
Reference Values
Systole / drug effects
Time Factors
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin; 70-18-8/Glutathione; 83150-76-9/Octreotide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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