| Glutathione regulates the transfer of iron-sulfur cluster from monothiol and dithiol glutaredoxins to apo ferredoxin. | |
| | |
MedLine Citation:
|
PMID: 22886498 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Holo glutaredoxin (Grx) is a homo-dimer that bridges a [2Fe-2S] cluster with two glutathione (GSH) ligands. In this study, both monothiol and dithiol holo Grxs are found capable of transferring their iron-sulfur (FeS) cluster to an apo ferredoxin (Fdx) through direct interaction, regardless of FeS cluster stability in holo Grxs. The ligand GSH molecules in holo Grxs are unstable and can be exchanged with free GSH, which inhibits the FeS cluster transfer from holo Grxs to apo Fdx. This phenomenon suggests a novel role of GSH in FeS cluster trafficking. |
| | |
Authors:
|
Lei Wang; Bingjie Ouyang; Yifei Li; Yingang Feng; Jean-Pierre Jacquot; Nicolas Rouhier; Bin Xia |
Related Documents
:
|
22820668 - Charge-order driven proton arrangement in a hydrogen-bonded charge-transfer complex bas... 20630738 - Polypyrrole nanowire modified with gly-gly-his tripeptide for electrochemical detection... 15835658 - Controlled, rapid deposition of structured coatings from micro- and nanoparticle suspen... 22606148 - 4-chloro-n'-(3,5-dibromo-2-hy-droxy-benzyl-idene)benzohydrazide. 11670158 - Reactivity of the acyclic diazadioxa redox active ligand [(c(5)h(5))fe(c(5)h(4)ch(2)n(c... 21837098 - 1-(5,5-dioxido-10h-phenothia-zin-10-yl)ethanone. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-8-12 |
Journal Detail:
|
Title: Protein & cell Volume: - ISSN: 1674-8018 ISO Abbreviation: Protein Cell Publication Date: 2012 Aug |
Date Detail:
|
Created Date: 2012-8-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101532368 Medline TA: Protein Cell Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Beijing Nuclear Magnetic Resonance Center, Peking University, Beijing, 100871, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Proteomic characteristics of the liver and skeletal muscle in the Chinese tree shrew (Tupaia belange...
Next Document: Efficacy of dialysis in peritoneal dialysis: utility of bioimpedance to calculate Kt/V and the searc...