Document Detail


Glutathione regulates the transfer of iron-sulfur cluster from monothiol and dithiol glutaredoxins to apo ferredoxin.
MedLine Citation:
PMID:  22886498     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Holo glutaredoxin (Grx) is a homo-dimer that bridges a [2Fe-2S] cluster with two glutathione (GSH) ligands. In this study, both monothiol and dithiol holo Grxs are found capable of transferring their iron-sulfur (FeS) cluster to an apo ferredoxin (Fdx) through direct interaction, regardless of FeS cluster stability in holo Grxs. The ligand GSH molecules in holo Grxs are unstable and can be exchanged with free GSH, which inhibits the FeS cluster transfer from holo Grxs to apo Fdx. This phenomenon suggests a novel role of GSH in FeS cluster trafficking.
Authors:
Lei Wang; Bingjie Ouyang; Yifei Li; Yingang Feng; Jean-Pierre Jacquot; Nicolas Rouhier; Bin Xia
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-12
Journal Detail:
Title:  Protein & cell     Volume:  3     ISSN:  1674-8018     ISO Abbreviation:  Protein Cell     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-28     Completed Date:  2013-01-03     Revised Date:  2014-03-13    
Medline Journal Info:
Nlm Unique ID:  101532368     Medline TA:  Protein Cell     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  714-21     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Circular Dichroism
Dimerization
Ferredoxins / chemistry*,  metabolism
Glutaredoxins / chemistry*,  metabolism
Glutathione / metabolism*
Iron / chemistry*
Ligands
Magnetic Resonance Spectroscopy
Sulfhydryl Compounds / chemistry*
Sulfur / chemistry*
Toluene / analogs & derivatives*,  chemistry
Chemical
Reg. No./Substance:
0/Ferredoxins; 0/Glutaredoxins; 0/Ligands; 0/Sulfhydryl Compounds; 0/apoferredoxin; 3FPU23BG52/Toluene; 496-74-2/dithiol; 70FD1KFU70/Sulfur; E1UOL152H7/Iron; GAN16C9B8O/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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