| Glutathione regeneration in calcium-loaded erythrocytes: a possible relationship among calcium accumulation, ATP decrement and oxidative damage. | |
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MedLine Citation:
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PMID: 7553347 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glutathione (GSH) regeneration was studied in rabbit erythrocytes which were loaded with calcium using ionophore A23187. Calcium-loading induced by A23187 and various concentrations of CaCl2 caused a dose-dependent depression in red cell GSH regeneration. The lowered GSH regeneration was mainly due to reduction of ATP level. In an experiment using haemolysate, the effect of calcium per se was negligible, while magnesium strongly affected GSH regeneration by controlling the rate of hexokinase reaction. These results indicate a possibility that cation perturbation, metabolic decay and oxidative damage are all interrelated in the erythrocyte aging process. |
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Authors:
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M Kurata; M Suzuki |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology Volume: 109 ISSN: 1096-4959 ISO Abbreviation: Comp. Biochem. Physiol. B, Biochem. Mol. Biol. Publication Date: 1994 Oct-Nov |
Date Detail:
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Created Date: 1995-11-07 Completed Date: 1995-11-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9516061 Medline TA: Comp Biochem Physiol B Biochem Mol Biol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 305-12 Citation Subset: IM |
Affiliation:
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Department of Veterinary Medicine, Faculty of Agriculture, Gifu University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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blood* Animals Calcimycin / pharmacology* Calcium / blood, pharmacology* Erythrocyte Deformability / drug effects Erythrocytes / drug effects*, metabolism Glutathione / blood* Male Oxidative Stress / drug effects* Rabbits |
| Chemical | |
Reg. No./Substance:
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52665-69-7/Calcimycin; 56-65-5/Adenosine Triphosphate; 70-18-8/Glutathione; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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