Document Detail


Glutathione regeneration in calcium-loaded erythrocytes: a possible relationship among calcium accumulation, ATP decrement and oxidative damage.
MedLine Citation:
PMID:  7553347     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glutathione (GSH) regeneration was studied in rabbit erythrocytes which were loaded with calcium using ionophore A23187. Calcium-loading induced by A23187 and various concentrations of CaCl2 caused a dose-dependent depression in red cell GSH regeneration. The lowered GSH regeneration was mainly due to reduction of ATP level. In an experiment using haemolysate, the effect of calcium per se was negligible, while magnesium strongly affected GSH regeneration by controlling the rate of hexokinase reaction. These results indicate a possibility that cation perturbation, metabolic decay and oxidative damage are all interrelated in the erythrocyte aging process.
Authors:
M Kurata; M Suzuki
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology     Volume:  109     ISSN:  1096-4959     ISO Abbreviation:  Comp. Biochem. Physiol. B, Biochem. Mol. Biol.     Publication Date:    1994 Oct-Nov
Date Detail:
Created Date:  1995-11-07     Completed Date:  1995-11-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9516061     Medline TA:  Comp Biochem Physiol B Biochem Mol Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  305-12     Citation Subset:  IM    
Affiliation:
Department of Veterinary Medicine, Faculty of Agriculture, Gifu University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / blood*
Animals
Calcimycin / pharmacology*
Calcium / blood,  pharmacology*
Erythrocyte Deformability / drug effects
Erythrocytes / drug effects*,  metabolism
Glutathione / blood*
Male
Oxidative Stress / drug effects*
Rabbits
Chemical
Reg. No./Substance:
52665-69-7/Calcimycin; 56-65-5/Adenosine Triphosphate; 70-18-8/Glutathione; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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