Document Detail


Glutathione reductase is expressed at high levels in pancreatic islet cells.
MedLine Citation:
PMID:  15720826     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Reactive oxygen species are, at least partly, involved in the diabetogenic agent-induced dysfunction of pancreatic beta-cells because the expression of antioxidative and redox proteins is low. We examined the levels of antioxidant/redox proteins, peroxiredoxins-1, -4, and -6 and glutathione reductase (GR), by immunohistochemistry and found that the expression of GR was very high in pancreatic islet cells compared to exocrine cells. When diabetes was induced by an intravenous injection of streptozotocin, the pre-administration of 1,3-bis[2-chloroethyl]-1-nitrosourea, an irreversible inhibitor of GR, made islet cells more vulnerable to streptozotocin. These data point to a pivotal role of the glutathione redox system in pancreatic islet cells against diabetogenic stress.
Authors:
Yuki Nagaoka; Yoshihito Iuchi; Yoshitaka Ikeda; Junichi Fujii
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Redox report : communications in free radical research     Volume:  9     ISSN:  1351-0002     ISO Abbreviation:  Redox Rep.     Publication Date:  2004  
Date Detail:
Created Date:  2005-02-21     Completed Date:  2005-07-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9511366     Medline TA:  Redox Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  321-4     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Yamagata University School of Medicine, Yamagata, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carmustine / pharmacology
Diabetes Mellitus, Experimental / metabolism*
Glutathione Reductase / immunology,  metabolism*
Heat-Shock Proteins / metabolism
Immunohistochemistry
Islets of Langerhans / enzymology*
Oxidation-Reduction
Peroxidases / metabolism
Peroxiredoxins
Rats
Rats, Wistar
Streptozocin
Chemical
Reg. No./Substance:
0/Heat-Shock Proteins; 154-93-8/Carmustine; 18883-66-4/Streptozocin; EC 1.11.1.-/Peroxidases; EC 1.11.1.14/Prdx1 protein, rat; EC 1.11.1.15/Peroxiredoxins; EC 1.11.1.15/Prdx4 protein, rat; EC 1.8.1.7/Glutathione Reductase

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