| Glutathione reductase is expressed at high levels in pancreatic islet cells. | |
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MedLine Citation:
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PMID: 15720826 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reactive oxygen species are, at least partly, involved in the diabetogenic agent-induced dysfunction of pancreatic beta-cells because the expression of antioxidative and redox proteins is low. We examined the levels of antioxidant/redox proteins, peroxiredoxins-1, -4, and -6 and glutathione reductase (GR), by immunohistochemistry and found that the expression of GR was very high in pancreatic islet cells compared to exocrine cells. When diabetes was induced by an intravenous injection of streptozotocin, the pre-administration of 1,3-bis[2-chloroethyl]-1-nitrosourea, an irreversible inhibitor of GR, made islet cells more vulnerable to streptozotocin. These data point to a pivotal role of the glutathione redox system in pancreatic islet cells against diabetogenic stress. |
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Authors:
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Yuki Nagaoka; Yoshihito Iuchi; Yoshitaka Ikeda; Junichi Fujii |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Redox report : communications in free radical research Volume: 9 ISSN: 1351-0002 ISO Abbreviation: Redox Rep. Publication Date: 2004 |
Date Detail:
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Created Date: 2005-02-21 Completed Date: 2005-07-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9511366 Medline TA: Redox Rep Country: England |
Other Details:
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Languages: eng Pagination: 321-4 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Yamagata University School of Medicine, Yamagata, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carmustine / pharmacology Diabetes Mellitus, Experimental / metabolism* Glutathione Reductase / immunology, metabolism* Heat-Shock Proteins / metabolism Immunohistochemistry Islets of Langerhans / enzymology* Oxidation-Reduction Peroxidases / metabolism Peroxiredoxins Rats Rats, Wistar Streptozocin |
| Chemical | |
Reg. No./Substance:
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0/Heat-Shock Proteins; 154-93-8/Carmustine; 18883-66-4/Streptozocin; EC 1.11.1.-/Peroxidases; EC 1.11.1.14/Prdx1 protein, rat; EC 1.11.1.15/Peroxiredoxins; EC 1.11.1.15/Prdx4 protein, rat; EC 1.8.1.7/Glutathione Reductase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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