| Glutathione reductase activity, riboflavin status, and disease activity in rheumatoid arthritis. | |
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MedLine Citation:
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PMID: 8976642 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To measure erythrocyte glutathione reductase (EGR) activity and riboflavin status, and their relations to disease activity, in rheumatoid arthritis patients compared to healthy controls. METHODS: Patients with rheumatoid arthritis were classified as active if there were features of articular inflammation which required initiation or change of disease modifying therapy, and as inactive if they had little evidence of articular inflammation. EGR was measured in patients and healthy controls by a functional assay with or without the addition of flavin adenine dinucleotide (FAD). The ratio of stimulated EGR (with FAD added) to basal EGR (no added FAD), which measures riboflavin status, is known as the EGR activation coefficient (EGRAC). An EGRAC > or = 1.3 represents biochemical riboflavin deficiency. RESULTS: 91 patients with rheumatoid arthritis, including 57 with active disease, and 220 healthy controls were studied. Both basal and stimulated EGR were significantly higher in patients with rheumatoid arthritis (P = 0.0001) than in controls. Biochemical riboflavin deficiency was identified in 41% controls and 33% patients with active rheumatoid arthritis but was significantly less frequent (9%) in patients with inactive compared to active disease (P = 0.02) or healthy controls (P = 0.0006). Pain score, articular index, C reactive protein, and erythrocyte sedimentation rate were increased in patients with riboflavin deficiency (all P < 0.02). CONCLUSIONS: Higher basal and stimulated EGR might be expected in patients with rheumatoid arthritis in response to chronic oxidative stress due to synovial inflammation. The association of riboflavin deficiency with increased disease activity suggests that impaired EGR activity could facilitate continuing inflammation in these patients. |
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Authors:
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D M Mulherin; D I Thurnham; R D Situnayake |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of the rheumatic diseases Volume: 55 ISSN: 0003-4967 ISO Abbreviation: Ann. Rheum. Dis. Publication Date: 1996 Nov |
Date Detail:
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Created Date: 1997-01-09 Completed Date: 1997-01-09 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 837-40 Citation Subset: IM |
Affiliation:
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Department of Rheumatology, City Hospital NHS Trust, Birmingham, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arthritis, Rheumatoid / metabolism*, physiopathology Enzyme Activation Female Flavin-Adenine Dinucleotide / metabolism Glutathione Reductase / blood, metabolism* Humans Male Middle Aged Pain Measurement Riboflavin Deficiency* / enzymology Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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146-14-5/Flavin-Adenine Dinucleotide; EC 1.8.1.7/Glutathione Reductase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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