Document Detail

Glutathione reductase activity correlates with concentration of extracellular matrix degradation products in synovial fluid from patients with joint diseases.
MedLine Citation:
PMID:  19847325     Owner:  NLM     Status:  MEDLINE    
The mechanisms underlying cartilage matrix degradation in joint diseases is not fully understood but reactive oxygen species are implicated as main causative factors. Comparative studies of glutathione reductase (GR) activity in synovial fluid from patients with rheumatoid arthritis (RA), reactive arthritis (ReA) and osteoarthritis (OA) as well as correlations between GR activity and concentration of the major cartilage components in synovial fluid are presented in this study. We found significantly higher activity of GR in RA (about three-fold) and ReA (about two-fold) than in OA. In RA and ReA patients, GR activity in synovial fluid correlates negatively with the concentrations of collagen and degradation products of sulfated glycosaminoglycans. In OA patients the activity of GR was significantly lower than in RA and ReA, which positively correlated with the concentration of collagen and showed a tendency for positive correlation with the degradation products of sulfated glycosaminoglycans. Our results suggest that in RA and ReA patients increased activity of GR does not prevent the increased degradation of collagen and proteoglycans by ROS.
Krystyna Sredzi?ska; Anna Galicka; Halina Porowska; ?ukasz Sredzi?ski; Tadeusz Porowski; Janusz Popko
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Publication Detail:
Type:  Journal Article     Date:  2009-10-22
Journal Detail:
Title:  Acta biochimica Polonica     Volume:  56     ISSN:  1734-154X     ISO Abbreviation:  Acta Biochim. Pol.     Publication Date:  2009  
Date Detail:
Created Date:  2010-01-12     Completed Date:  2010-02-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  14520300R     Medline TA:  Acta Biochim Pol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  635-40     Citation Subset:  IM    
Department of Medical Chemistry, Medical University of Bia?ystok, Bia?ystok, Poland.
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MeSH Terms
Arthritis, Reactive / enzymology*
Arthritis, Rheumatoid / enzymology*
Collagen / metabolism
Extracellular Matrix / metabolism
Glutathione Reductase / metabolism*
Middle Aged
Osteoarthritis / enzymology*
Reactive Oxygen Species / metabolism
Synovial Fluid / metabolism*
Reg. No./Substance:
0/Reactive Oxygen Species; 9007-34-5/Collagen; EC Reductase

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