Document Detail


Glutathione reductase activity correlates with concentration of extracellular matrix degradation products in synovial fluid from patients with joint diseases.
MedLine Citation:
PMID:  19847325     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mechanisms underlying cartilage matrix degradation in joint diseases is not fully understood but reactive oxygen species are implicated as main causative factors. Comparative studies of glutathione reductase (GR) activity in synovial fluid from patients with rheumatoid arthritis (RA), reactive arthritis (ReA) and osteoarthritis (OA) as well as correlations between GR activity and concentration of the major cartilage components in synovial fluid are presented in this study. We found significantly higher activity of GR in RA (about three-fold) and ReA (about two-fold) than in OA. In RA and ReA patients, GR activity in synovial fluid correlates negatively with the concentrations of collagen and degradation products of sulfated glycosaminoglycans. In OA patients the activity of GR was significantly lower than in RA and ReA, which positively correlated with the concentration of collagen and showed a tendency for positive correlation with the degradation products of sulfated glycosaminoglycans. Our results suggest that in RA and ReA patients increased activity of GR does not prevent the increased degradation of collagen and proteoglycans by ROS.
Authors:
Krystyna Sredzi?ska; Anna Galicka; Halina Porowska; ?ukasz Sredzi?ski; Tadeusz Porowski; Janusz Popko
Related Documents :
16095115 - A retrospective study of the fluctuation in serum levels of anti-cyclic citrullinated p...
23102805 - Relationship between monoclonal gammopathy and cardiac amyloid type.
23178565 - Early-onset alzheimer's disease: nonamnestic subtypes and type 2 ad.
18061135 - Immunologic markers as potential predictors of systemic autoimmune disease in patients ...
11514245 - Electromyographic differentiation of tremors.
3391405 - Hypnogenic paroxysmal dystonia: a new type of parasomnia?
Publication Detail:
Type:  Journal Article     Date:  2009-10-22
Journal Detail:
Title:  Acta biochimica Polonica     Volume:  56     ISSN:  1734-154X     ISO Abbreviation:  Acta Biochim. Pol.     Publication Date:  2009  
Date Detail:
Created Date:  2010-01-12     Completed Date:  2010-02-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  14520300R     Medline TA:  Acta Biochim Pol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  635-40     Citation Subset:  IM    
Affiliation:
Department of Medical Chemistry, Medical University of Bia?ystok, Bia?ystok, Poland. krystyna@umwb.edu.pl
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Arthritis, Reactive / enzymology*
Arthritis, Rheumatoid / enzymology*
Collagen / metabolism
Extracellular Matrix / metabolism
Female
Glutathione Reductase / metabolism*
Humans
Male
Middle Aged
Osteoarthritis / enzymology*
Reactive Oxygen Species / metabolism
Synovial Fluid / metabolism*
Chemical
Reg. No./Substance:
0/Reactive Oxygen Species; 9007-34-5/Collagen; EC 1.8.1.7/Glutathione Reductase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The role of the murine motor cortex in action duration and order.
Next Document:  Recent applications of intramolecular Diels-Alder reactions to natural product synthesis.