| Glutathione redox control of asthma: From molecular mechanisms to therapeutic opportunities. | |
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MedLine Citation:
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PMID: 22304503 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Asthma is a chronic inflammatory disorder of the airways associated with airway hyperresponsiveness and airflow limitation in response to specific triggers. Whereas inflammation is important for tissue regeneration and wound healing, the profound and sustained inflammatory response associated with asthma may result in airway "remodeling" which involves smooth muscle hypertrophy, epithelial goblet-cell hyperplasia and permanent deposition of airway extracellular matrix proteins. Although the specific mechanisms responsible for asthma are still being unraveled, free radicals such as reactive oxygen species (ROS) and reactive nitrogen species (RNS) are important mediators of airway tissue damage that are increased in subjects with asthma. There is also a growing body of literature implicating disturbances in oxidation/reduction ("redox") reactions and impaired antioxidant defenses as a risk factor for asthma development and asthma severity. Ultimately, these redox-related perturbations result in a vicious cycle of airway inflammation and injury that is not always amenable to current asthma therapy, particularly in cases of severe asthma. This review will discuss disruptions of redox signaling and control in asthma with a focus on the thiol, glutathione (GSH). First, GSH synthesis, GSH distribution, and GSH function and homeostasis are discussed. We then review the literature related to GSH redox balance in health and asthma, with an emphasis on human studies. Finally, therapeutic opportunities to restore the GSH redox balance in subjects with asthma are discussed. |
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Authors:
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Anne M Fitzpatrick; Dean P Jones; Lou Ann S Brown |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-5 |
Journal Detail:
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Title: Antioxidants & redox signaling Volume: - ISSN: 1557-7716 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888899 Medline TA: Antioxid Redox Signal Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Emory University, Pediatrics, 2015 Uppergate Drive, Atlanta, Georgia, United States, 30322; anne.fitzpatrick@emory.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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