Document Detail


Glutathione and nitrosoglutathione in macrophage defense against Mycobacterium tuberculosis.
MedLine Citation:
PMID:  15731094     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We demonstrate that Mycobacterium tuberculosis grown in vitro is sensitive to glutathione and its derivative S-nitrosoglutathione. Furthermore, our infection studies with J774.1 macrophages indicate that glutathione is essential for the control of the intracellular growth of M. tuberculosis. This study indicates the important role of glutathione in the control of macrophages by M. tuberculosis.
Authors:
Vishwanath Venketaraman; Yaswant K Dayaram; Meliza T Talaue; Nancy D Connell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Infection and immunity     Volume:  73     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-02-25     Completed Date:  2005-04-01     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1886-9     Citation Subset:  IM    
Affiliation:
Department of Medicine, UMDNJ-New Jersey Medical School, 225 Warren St., Newark, NJ 07103, USA. venketvi@umdnj.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Line
Glutathione / metabolism,  pharmacology*
Humans
Interferon-gamma / pharmacology
Lipopolysaccharides / pharmacology
Macrophage Activation
Macrophages / immunology*,  microbiology*
Mice
Mycobacterium tuberculosis / drug effects*,  growth & development*
S-Nitrosoglutathione / pharmacology*
Grant Support
ID/Acronym/Agency:
R01AI34436/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Lipopolysaccharides; 57564-91-7/S-Nitrosoglutathione; 70-18-8/Glutathione; 82115-62-6/Interferon-gamma
Comments/Corrections

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