| Glutathione-mediated response to acid stress in the probiotic bacterium, Lactobacillus salivarius. | |
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MedLine Citation:
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PMID: 20349113 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lactobacillus salivarius, a probiotic bacterium, encounters acidic conditions in its passage through the gastrointestinal tract of human and animal hosts. We studied the effect of a rapid downshift in extracellular pH from 6.5 to 4 on cell growth. The maximum growth rate was higher in low pH medium with glutathione supplementation than without. Cells developed a GSH-mediated acid-tolerance response and, when grown with 0.5 mM GSH, reached a higher final density than with other conditions. These findings suggest that the increased growth rate is caused by uptake of GSH which acts as a nutrient source as well as having protective functions, allowing for continued growth. |
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Authors:
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Kibeom Lee; Kyungbae Pi; Eun Bae Kim; Beom-Seop Rho; Sang-Kee Kang; Hong Gu Lee; Yun-Jaie Choi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-27 |
Journal Detail:
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Title: Biotechnology letters Volume: 32 ISSN: 1573-6776 ISO Abbreviation: Biotechnol. Lett. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-17 Completed Date: 2010-09-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8008051 Medline TA: Biotechnol Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 969-72 Citation Subset: IM |
Affiliation:
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Department of Biotechnology, Songdo Technopark, 6F Michuhol Tower, 7-50 Songdo-Dong, Yeonsu-Gu, Incheon, 406-840, Republic of Korea. klee02@empal.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acids
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toxicity* Bacterial Proteins / analysis Biomass Culture Media / chemistry Glutathione / metabolism* Humans Lactobacillus / chemistry, drug effects*, growth & development, physiology* Probiotics* Stress, Physiological* |
| Chemical | |
Reg. No./Substance:
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0/Acids; 0/Bacterial Proteins; 0/Culture Media; 70-18-8/Glutathione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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