| Glutathione levels in human platelets display a circadian rhythm in vitro. | |
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MedLine Citation:
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PMID: 4089839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glutathione (GSH) levels were measured in platelet-rich plasma (PRP) and concentrates at 4 hour intervals during storage. The values fell steadily during the first several hours after collection at 9:00 a.m., reaching the lowest level at midnight, 14 hours later. Subsequently, the levels rose to a new peak value at 4:00 a.m. GSH levels continued to show cyclic variation over the 48 hours examined in this study. Change in schedules of light and dark under which the platelets were stored had no effect on GSH periodicity. Platelets from night shift workers also displayed a similar periodicity to that of day workers. Erythrocytes failed to demonstrate a similar time related variation in GSH levels during storage. |
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Authors:
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E Radha; T D Hill; G H Rao; J G White |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Thrombosis research Volume: 40 ISSN: 0049-3848 ISO Abbreviation: Thromb. Res. Publication Date: 1985 Dec |
Date Detail:
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Created Date: 1986-02-24 Completed Date: 1986-02-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0326377 Medline TA: Thromb Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 823-31 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Platelets / drug effects, metabolism* Buthionine Sulfoximine Circadian Rhythm* Darkness Erythrocytes / metabolism Glutathione / analogs & derivatives, blood* Glutathione Disulfide Humans Light Methionine Sulfoximine / analogs & derivatives, pharmacology Oxidation-Reduction Work Schedule Tolerance |
| Grant Support | |
ID/Acronym/Agency:
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CA-21737/CA/NCI NIH HHS; GM-22167/GM/NIGMS NIH HHS; HL-11880/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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1982-67-8/Methionine Sulfoximine; 27025-41-8/Glutathione Disulfide; 5072-26-4/Buthionine Sulfoximine; 70-18-8/Glutathione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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