Document Detail


Glutathione levels in human platelets display a circadian rhythm in vitro.
MedLine Citation:
PMID:  4089839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glutathione (GSH) levels were measured in platelet-rich plasma (PRP) and concentrates at 4 hour intervals during storage. The values fell steadily during the first several hours after collection at 9:00 a.m., reaching the lowest level at midnight, 14 hours later. Subsequently, the levels rose to a new peak value at 4:00 a.m. GSH levels continued to show cyclic variation over the 48 hours examined in this study. Change in schedules of light and dark under which the platelets were stored had no effect on GSH periodicity. Platelets from night shift workers also displayed a similar periodicity to that of day workers. Erythrocytes failed to demonstrate a similar time related variation in GSH levels during storage.
Authors:
E Radha; T D Hill; G H Rao; J G White
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Thrombosis research     Volume:  40     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-02-24     Completed Date:  1986-02-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  823-31     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Platelets / drug effects,  metabolism*
Buthionine Sulfoximine
Circadian Rhythm*
Darkness
Erythrocytes / metabolism
Glutathione / analogs & derivatives,  blood*
Glutathione Disulfide
Humans
Light
Methionine Sulfoximine / analogs & derivatives,  pharmacology
Oxidation-Reduction
Work Schedule Tolerance
Grant Support
ID/Acronym/Agency:
CA-21737/CA/NCI NIH HHS; GM-22167/GM/NIGMS NIH HHS; HL-11880/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
1982-67-8/Methionine Sulfoximine; 27025-41-8/Glutathione Disulfide; 5072-26-4/Buthionine Sulfoximine; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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