Document Detail

Glutathione improves the cold resistance of Lactobacillus sanfranciscensis by physiological regulation.
MedLine Citation:
PMID:  22608235     Owner:  NLM     Status:  In-Data-Review    
The microenvironmental manipulation of glutathione (GSH) on improving cold resistance of Lactobacillus sanfranciscensis DSM 20451(T) was investigated in this study. It was proved that GSH relieves the metabolic disorder of cells under cold stress, and prevents the decreased activities of related key enzymes such as pyruvate kinase (PK), glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and lactate dehydrogenase (LDH) upon cold challenges. Higher intracellular ATP level was also found in cells with GSH under cold stress. Moreover, cells with imported GSH had significantly higher intracellular than the control during cold treatment. In addition, proteomics analysis showed more exciting findings that the protective function of GSH under cold stress was related to metabolic regulation and the multi-control against induced cross-stresses. These results broaden the knowledge about the physiological function of GSH, and suggest a practicable approach to improve the cold resistance of L. sanfranciscensis, a starter culture for sourdough, by the addition of GSH.
Juan Zhang; Yin Li; Wei Chen; Guo-Cheng Du; Jian Chen
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Publication Detail:
Type:  Journal Article     Date:  2012-04-10
Journal Detail:
Title:  Food microbiology     Volume:  31     ISSN:  1095-9998     ISO Abbreviation:  Food Microbiol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-05-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8601127     Medline TA:  Food Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  285-92     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
State Key Laboratory of Food Science and Technology, Jiangnan University, China; School of Biotechnology, Jiangnan University, China.
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