Document Detail


Glutathione, glutathione reductase and glutathione S-transferase activities in erythrocytes and lymphocytes in chronic renal disease.
MedLine Citation:
PMID:  6463365     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Erythrocyte and lymphocyte reduced glutathione (GSH) levels, and glutathione reductase (GR) and glutathione S-transferase (GST) activities have been investigated in uremic patients pre- and post-dialysis and normal subjects of the same age span. GSH levels and GST activities in erythrocytes and lymphocytes and GR activity in lymphocytes from uremic patients were higher as compared to the corresponding controls. Dialysis resulted in a 17% decrease in GSH levels in erythrocytes. Hemodialysis did not significantly alter erythrocyte GST and GR activities. Hemodialysis produced a 50% decrease in lymphocyte GST activity and a 32% decrease in lymphocyte GR activity. Elevated levels of GSH and increased activities of GST and GR in blood cells of uremic patients may be associated with a compensatory protective mechanism against accumulating toxic wastes in uremic plasma.
Authors:
F H El-Rashidy; W A Al-Turk; S J Stohs
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  44     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-08-31     Completed Date:  1984-08-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  423-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Erythrocytes / metabolism*
Female
Glutathione / blood*
Glutathione Reductase / blood*
Glutathione Synthase / blood*
Humans
Kidney Failure, Chronic / blood*,  therapy
Lymphocytes / metabolism*
Male
Middle Aged
Peptide Synthases / blood*
Renal Dialysis
Chemical
Reg. No./Substance:
70-18-8/Glutathione; EC 1.8.1.7/Glutathione Reductase; EC 6.3.2.-/Peptide Synthases; EC 6.3.2.3/Glutathione Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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