| Glutathione disulfide formation and lipid peroxidation during cardiac ischemia and reflow in the dog in vivo. | |
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MedLine Citation:
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PMID: 2818585 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The content of glutathione disulfide (GSSG) in tissue, coronary sinus blood plasma, and in cardiac lymph was measured in a well-characterized model of regional cardiac ischemia and reflow in dogs in vivo in order to assess the magnitude of the oxidant stress produced. No increase in GSSG content was observed during 60 min of occlusion of the circumflex or left anterior descending arteries, or during up to 70 min of reflow. The contents of 11-, 12-, and 15-hydroxyeicosatetraenoates (HETEs) in total lipids also were not increased following 60 min of regional ischemia and up to 60 min of reflow. In addition, global ischemia produced by aortic crossclamping and cardiopulmonary bypass did not increase HETE content. In contrast, infusion of tertiary butyl hydroperoxide (tBHP) into the left atrium produced readily measurable increases in GSSG content with or without prior induction of myocardial ischemia. Infusion of tBHP also increased tissue contents of the HETEs. These findings indicate that the canine myocardium subjected to ischemia-reflow conditions does not generate large amounts of reactive oxygen and does not form significant amounts lipid peroxidation products. |
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Authors:
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M L Lenz; L H Michael; C V Smith; H Hughes; S B Shappell; A A Taylor; M L Entman; J R Mitchell |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 164 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1989 Oct |
Date Detail:
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Created Date: 1989-12-11 Completed Date: 1989-12-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 722-7 Citation Subset: IM |
Affiliation:
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Department of Medicine, Baylor College of Medicine, Houston, TX 77030. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiopulmonary Bypass Coronary Disease / metabolism* Coronary Vessels / physiology* Disease Models, Animal Dogs Female Glutathione / blood, metabolism Glutathione Disulfide Lipid Peroxidation* Lymph / metabolism Male Myocardial Reperfusion* Myocardium / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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GM 34120/GM/NIGMS NIH HHS; HL 23161/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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27025-41-8/Glutathione Disulfide; 70-18-8/Glutathione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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