Document Detail


Glutathione disulfide formation and lipid peroxidation during cardiac ischemia and reflow in the dog in vivo.
MedLine Citation:
PMID:  2818585     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The content of glutathione disulfide (GSSG) in tissue, coronary sinus blood plasma, and in cardiac lymph was measured in a well-characterized model of regional cardiac ischemia and reflow in dogs in vivo in order to assess the magnitude of the oxidant stress produced. No increase in GSSG content was observed during 60 min of occlusion of the circumflex or left anterior descending arteries, or during up to 70 min of reflow. The contents of 11-, 12-, and 15-hydroxyeicosatetraenoates (HETEs) in total lipids also were not increased following 60 min of regional ischemia and up to 60 min of reflow. In addition, global ischemia produced by aortic crossclamping and cardiopulmonary bypass did not increase HETE content. In contrast, infusion of tertiary butyl hydroperoxide (tBHP) into the left atrium produced readily measurable increases in GSSG content with or without prior induction of myocardial ischemia. Infusion of tBHP also increased tissue contents of the HETEs. These findings indicate that the canine myocardium subjected to ischemia-reflow conditions does not generate large amounts of reactive oxygen and does not form significant amounts lipid peroxidation products.
Authors:
M L Lenz; L H Michael; C V Smith; H Hughes; S B Shappell; A A Taylor; M L Entman; J R Mitchell
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  164     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-12-11     Completed Date:  1989-12-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  722-7     Citation Subset:  IM    
Affiliation:
Department of Medicine, Baylor College of Medicine, Houston, TX 77030.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiopulmonary Bypass
Coronary Disease / metabolism*
Coronary Vessels / physiology*
Disease Models, Animal
Dogs
Female
Glutathione / blood,  metabolism
Glutathione Disulfide
Lipid Peroxidation*
Lymph / metabolism
Male
Myocardial Reperfusion*
Myocardium / metabolism*
Grant Support
ID/Acronym/Agency:
GM 34120/GM/NIGMS NIH HHS; HL 23161/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
27025-41-8/Glutathione Disulfide; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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