Document Detail

Glutathione depletion and rabbit renal medulla 6-ketoPGF1 alpha and TxB2: levels in vivo and following homogenate incubation in vitro.
MedLine Citation:
PMID:  1516728     Owner:  NLM     Status:  MEDLINE    
1. The effect of glutathione (GSH) depletion on rabbit renal medullary homogenate 6-ketoPGF1 alpha and TxB2 synthesizing capability was investigated. 2. GSH depletion in vivo with diethyl maleate (DEM) produced higher (P less than 0.05) 6-ketoPGF1 alpha and TxB2 renal medullary levels compared to controls. Homogenization and incubation lowered (P less than 0.05) GSH such that there were no differences in GSH between treatments after 5 min of incubation. By 30 min, GSH was lower (P less than 0.05) and 6-ketoPGF1 alpha higher (P less than 0.05) in homogenates from controls in comparison to those from DEM-treated rabbits. 3. The results indicate GSH depletion increased 6-ketoPGF1 alpha levels in rabbit renal medulla in vivo but subsequent GSH catabolism prevented assessing the effect of this GSH depletion on prostanoid synthesizing capability.
H H Nejad; W G Bottje
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The International journal of biochemistry     Volume:  24     ISSN:  0020-711X     ISO Abbreviation:  Int. J. Biochem.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-10-08     Completed Date:  1992-10-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0250365     Medline TA:  Int J Biochem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  561-4     Citation Subset:  IM    
Department of Animal and Poultry Sciences, University of Arkansas, Fayetteville 72701.
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MeSH Terms
6-Ketoprostaglandin F1 alpha / metabolism*
Glutathione / metabolism*
Kidney Medulla / metabolism*
Thromboxane B2 / metabolism*
Grant Support
Reg. No./Substance:
0/Maleates; 141-05-9/diethyl maleate; 54397-85-2/Thromboxane B2; 58962-34-8/6-Ketoprostaglandin F1 alpha; 70-18-8/Glutathione

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