Document Detail

Glutathione content of the small intestine: regulation and function.
MedLine Citation:
PMID:  8490011     Owner:  NLM     Status:  MEDLINE    
In ad lib.-fed rats the epithelium of the small intestine, like the liver, contains large quantities of glutathione, 17.0 and 32.4 nmol/mg protein respectively. Following 24 h food restriction the glutathione content in both tissues fell 53 and 69% respectively. Unlike the liver, however, the glutathione content of the intestinal mucosa is not regulated to a diurnal rhythm, suggesting that the liver may provide glutathione or glutathione precursors to maintain intestinal glutathione levels. Intestinal epithelial cell preparations obtained from 24 h food-deprived rats had depleted glutathione stores (50%) and as a consequence were more susceptible to the oxidizing effects of cumene hydroperoxide. These results suggest that if glutathione plays a major role in the defence of the intestinal mucosa from ingested toxins then depletion of this defence during periods of food restriction could significantly increase the susceptibility of the individual to toxins present in the diet.
F J Kelly
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of nutrition     Volume:  69     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-06-15     Completed Date:  1993-06-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  589-96     Citation Subset:  IM    
Department of Human Nutrition, University of Southampton.
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MeSH Terms
Benzene Derivatives / pharmacology
Circadian Rhythm
Epithelial Cells
Epithelium / drug effects,  metabolism
Food Deprivation / physiology
Glutathione / metabolism*
Intestinal Mucosa / drug effects,  metabolism*
Intestine, Small / metabolism*
Liver / metabolism
Rats, Wistar
Reg. No./Substance:
0/Benzene Derivatives; 70-18-8/Glutathione; 80-15-9/cumene hydroperoxide

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