| Glutathione S-transferases as a cefpiramide binding protein in rat liver. | |
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MedLine Citation:
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PMID: 7617548 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To clarify the intrahepatical transport mechanism of cefpiramide, we investigated effects of various agents mainly excreted into the bile by several different mechanisms on the biliary excretion of cefpiramide in rats. Sulfobromophthalein, indocyanine green, bilirubin and probenecid, known to be bound to glutathione S-transferases (GST) (EC 2.5.1.18) in liver cytosol, reduced the biliary excretion of cefpiramide, while neither secretory IgA, which is transported via vesicles in the liver, nor colchicine, which inhibits movements of vesicles, had any effect on the excretion of cefpiramide. Propranolol and metoprolol, metabolized by mixed function oxidases, had no effect on the biliary excretion of cefpiramide. In the chromatography of liver cytosol, the amount of sulfobromophthalein or benzylpenicillin bound to the GST fraction decreased in the presence of cefpiramide or probenecid. The study showed that cefpiramide was transported in the liver without relation to mixed function oxidases or vesichle-mediated transporting system, but in relation to GST which binds cefpiramide, sulfobromophthalein, benzylpenicillin and probenecid, indicating an important role of GST in the cefpiramide excretion into the bile. |
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Authors:
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A Guji; H Nishiya; M Aoki; I Ohyatsu; M Yamaguchi; Y Tokumura; H Sugiyama; T Miyashita; Y Ono; O Kunii |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pharmacology & toxicology Volume: 76 ISSN: 0901-9928 ISO Abbreviation: Pharmacol. Toxicol. Publication Date: 1995 Mar |
Date Detail:
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Created Date: 1995-08-24 Completed Date: 1995-08-24 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8702180 Medline TA: Pharmacol Toxicol Country: DENMARK |
Other Details:
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Languages: eng Pagination: 212-7 Citation Subset: IM |
Affiliation:
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Second Department of Internal Medicine, University of Teikyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carrier Proteins / metabolism* Cephalosporins / analysis, metabolism* Glutathione Transferase / metabolism* Liver / enzymology* Male Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Cephalosporins; 70797-11-4/cefpiramide; EC 2.5.1.18/Glutathione Transferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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