Document Detail


Glutathione S-transferases M1-1 and T1-1 as risk modifiers for renal cell cancer associated with occupational exposure to chemicals.
MedLine Citation:
PMID:  14504370     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: To investigate the possible interaction between occupational risk factors and genotype for glutathione S-transferases M1 and T1 (GSTM1 and GSTT1) in renal cell cancer (RCC). METHODS: One hundred patients with RCC and 200 outpatient controls were enrolled at Parma University Hospital. The polymorphisms of glutathione S-transferase M1-1 (GSTM1) and T1-1 (GSTT1) were investigated by PCR; occupational history was collected by a structured questionnaire. RESULTS: Subjects with GSTM1 present genotype showed higher risks for RCC, compared to GSTM1 null subjects, if exposed to metals (OR 2.73; 95% CI 0.91 to 8.22 v 1.14; 95% CI 0.46 to 2.82) or pesticides (OR 3.46; 95% CI 1.12 to 10.74 v 1.59; 95% CI 0.48 to 5.34). The GSTT1 present genotype also enhanced the risk (about twofold) of RCC among subjects exposed to solvents and pesticides, compared with those GSTT1 null. CONCLUSIONS: Results support the hypothesis that GSTM1 and GSTT1 polymorphisms can interact with several occupational exposures to significantly modify the risk of RCC among exposed subjects.
Authors:
L Buzio; G De Palma; P Mozzoni; M Tondel; C Buzio; I Franchini; O Axelson; A Mutti
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Occupational and environmental medicine     Volume:  60     ISSN:  1470-7926     ISO Abbreviation:  Occup Environ Med     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-09-23     Completed Date:  2003-10-16     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9422759     Medline TA:  Occup Environ Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  789-93     Citation Subset:  IM    
Affiliation:
Dept of Clinical Medicine, Nephrology and Health Sciences, University of Parma, Parma, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Carcinoma, Renal Cell / chemically induced*,  enzymology,  genetics
Case-Control Studies
Chemical Industry
Female
Genetic Predisposition to Disease
Glutathione Transferase / genetics*,  metabolism
Humans
Kidney Neoplasms / chemically induced*,  enzymology,  genetics
Logistic Models
Male
Middle Aged
Occupational Exposure / adverse effects*
Odds Ratio
Polymorphism, Genetic
Solvents / adverse effects*
Chemical
Reg. No./Substance:
0/Solvents; EC 2.5.1.-/glutathione S-transferase T1; EC 2.5.1.18/Glutathione Transferase; EC 2.5.1.18/glutathione S-transferase M1
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Mortality in workers in poultry slaughtering/processing plants: the Missouri poultry cohort study.
Next Document:  Knee disorders in the general population and their relation to occupation.