| Glutathione S-transferase M1 gene but not insulin-like growth factor-2 gene or epidermal growth factor gene is associated with prostate cancer. | |
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MedLine Citation:
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PMID: 16018936 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prostate cancer is the most common urologic malignancy involving multiple factors. There is evidence that suggests that detoxification enzymes and growth factors may play a role in the formation of prostate cancer. Our aim was to investigate whether polymorphisms of glutathione S-transferase M1 (GST M1), insulin-like growth factor-2 (IGF-2), and epidermal growth factor (EGFR) genes could be used as genetic markers for risk of prostate cancer. In this study, we compared the frequency of the polymorphisms of GST M1, IGF-2, and EGFR genes among 96 patients with prostate cancer and 121 healthy male volunteers from the same geographic area (age, older than 60 years). There was significant difference in the GST M1 genotype between the prostate cancer group and the control group (P=0.042). The GST M1 null genotype was significantly higher in the cancer group (59.4%) than in the control group (45.5%). However, our study did not reveal a significant association between prostate cancer and the distribution of the IGF-2 or EGFR genotypes. This study suggests that the GST M1 gene, but not the IGF-2 or the EGFR genes, may be a risk factor of developing prostate cancer in Taiwan. |
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Authors:
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Ming-Tsung Lai; Rong-Hsing Chen; Fuu-Jen Tsai; Lei Wan; Wen-Chi Chen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Urologic oncology Volume: 23 ISSN: 1078-1439 ISO Abbreviation: Urol. Oncol. Publication Date: 2005 Jul-Aug |
Date Detail:
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Created Date: 2005-07-15 Completed Date: 2005-11-01 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9805460 Medline TA: Urol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 225-9 Citation Subset: IM |
Affiliation:
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Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Case-Control Studies Genotype Glutathione Transferase / genetics* Humans Insulin-Like Growth Factor II / genetics Male Middle Aged Polymorphism, Genetic Prostatic Neoplasms / epidemiology, genetics*, physiopathology* Receptor, Epidermal Growth Factor / genetics Risk Factors Taiwan |
| Chemical | |
Reg. No./Substance:
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67763-97-7/Insulin-Like Growth Factor II; EC 2.5.1.18/Glutathione Transferase; EC 2.5.1.18/glutathione S-transferase M1; EC 2.7.10.1/Receptor, Epidermal Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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