Document Detail

Glutathione S-transferase M1, T1, and P1 polymorphisms as susceptibility factors for noise-induced temporary threshold shift.
MedLine Citation:
PMID:  19643173     Owner:  NLM     Status:  MEDLINE    
The generation of reactive oxygen species (ROS) is thought to be part of the mechanism underlying noise-induced hearing loss (NIHL). Glutathione is an important cellular antioxidant that limits cell damage by ROS. We aimed to determine the effect of genetic polymorphisms of glutathione S-transferase (GST) T1, GSTM1, and GSTP1, on temporary threshold shift (TTS) in 58 noise-exposed male workers from a steel factory. The pre-shift hearing impairment at high frequency (HF, average of 3, 4, and 6kHz) was 30.7dB HL (S.D.=19.3). The amount of daily noise exposure was 83.0dBA (S.D.=5.0). Noise-induced TTS at HF by pure-tone audiometry (PTA) was related to the daily noise exposure (p<0.05). Based on combinatory analysis, we found that individuals carrying all genotypes with GSTT1 null, GSTM1 null, and GSTP1 Ile(105)/Ile(105) were more susceptible to NIHL. These results suggest that pre-shift hearing impairment and daily noise exposure had impacts on TTS at HF by PTA. In addition, GST genetic polymorphisms may modify the susceptibility to noise-induced TTS.
Cheng-Yu Lin; Jiunn-Liang Wu; Tung-Sheng Shih; Perng-Jy Tsai; Yih-Min Sun; Yueliang Leon Guo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-28
Journal Detail:
Title:  Hearing research     Volume:  257     ISSN:  1878-5891     ISO Abbreviation:  Hear. Res.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-05     Completed Date:  2009-12-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  8-15     Citation Subset:  IM    
Department of Otolaryngology, Tainan Municipal Hospital, East District, Tainan City 701, Taiwan.
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MeSH Terms
Audiometry, Pure-Tone
Auditory Threshold*
Genetic Predisposition to Disease
Glutathione S-Transferase pi / genetics*
Glutathione Transferase / genetics*
Hearing Loss, Noise-Induced / enzymology,  etiology,  genetics*,  physiopathology
Middle Aged
Noise, Occupational / adverse effects*
Polymorphism, Single Nucleotide*
Regression Analysis
Risk Assessment
Risk Factors
Reg. No./Substance:
EC protein, human; EC S-Transferase pi; EC Transferase; EC S-transferase M1; EC transferase T1-1, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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