Document Detail

Glutaraldehyde-fixed bovine pericardium for right ventricular outflow enlargement.
MedLine Citation:
PMID:  2808496     Owner:  NLM     Status:  MEDLINE    
Right ventricular outflow tract enlargement using glutaraldehyde-fixed bovine pericardium was evaluated experimentally using the pig model. Twelve piglets (8-16 kg) underwent closure of surgically created, longitudinal right ventriculotomies using premeasured, round, bovine pericardial patches. Half of the animals had pulmonary artery banding to increase right sided pressures. The animals were studied an average of 5.1 months following surgery. Cardiac catheterization was performed on eight animals. Pressure measurements revealed no gradient across any outflow patch, and angiography showed no stenosis or dilatation. There was marked right ventricular hypertension in the banded animals. The hearts from all twelve animals were examined grossly and microscopically. There was endothelialization of all patches with no aneurysm formation. Measurements revealed that most patches had become oval shaped. There was no difference in patch size changes between banded and non-banded animals. The patches showed no significant size change in the longitudinal plane (average from 20.8 mm to 20.3 mm, 6.3% change); however, there was a significant decrease in the transverse size (20.8 mm to 17.3 mm, 16.0%) (p less than 0.001). The change in patch size was probably due to reshaping to conform to the longitudinal ventriculotomy and caused no narrowing. In this study, glutaraldehyde-fixed bovine pericardium appeared to be satisfactory for right ventricular outflow enlargement. Favorable qualities include ease of handling, hemostasis, and no aneurysm formation.
J W Mack; V C Smith; W J Ehler; J H Rogers; D L Brown; R L Eason
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of cardiovascular surgery     Volume:  30     ISSN:  0021-9509     ISO Abbreviation:  J Cardiovasc Surg (Torino)     Publication Date:    1989 Sep-Oct
Date Detail:
Created Date:  1989-12-18     Completed Date:  1989-12-18     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0066127     Medline TA:  J Cardiovasc Surg (Torino)     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  774-8     Citation Subset:  IM    
Department of Cardiothoracic Surgery, Wilford Hall USAF Medical Center, Lackland AFB, Texas.
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MeSH Terms
Endothelium, Vascular / physiology
Graft Survival / physiology
Heart Ventricles / surgery*
Pericardium / transplantation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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