Document Detail


Glutamine synthetase activity in Huntington's disease.
MedLine Citation:
PMID:  6128649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glutamine synthetase activity was measured in seven brain areas post-mortem from control patients, and those with Huntington's disease. The activity of the enzyme was reduced in the frontal and temporal cortex, putamen and cerebellum, but not in the hippocampus, thalamus or olivary nucleus. The results do not suggest a generalised deficiency of glutamine synthetase in Huntington's disease. However, as this enzyme is localised to astrocytic cells, the reduction in activity in areas of neuronal devastation, where the ration of astrocytes to neurones is increased, may reflect a greater functional deficit. The enzyme plays a crucial role in cerebral ammonia assimilation and its inhibition in laboratory animals is known to produce neuronal toxicity. A reduction in its activity in Huntington's disease may well contribute to the neuronal pathology in certain areas.
Authors:
C J Carter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  31     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1982 Sep 
Date Detail:
Created Date:  1983-01-19     Completed Date:  1983-01-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1151-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Ammonia
Autopsy
Brain / enzymology*,  metabolism
Glutamate-Ammonia Ligase / metabolism*
Humans
Huntington Disease / enzymology*,  metabolism
Proteins / metabolism
Chemical
Reg. No./Substance:
0/Proteins; 7664-41-7/Ammonia; EC 6.3.1.2/Glutamate-Ammonia Ligase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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