| Glutamine prevents gastric oxidative stress in an animal model of portal hypertension gastropathy. | |
| | |
MedLine Citation:
|
PMID: 21911895 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND RATIONALE: Portal hypertension (PHI) is a clinical syndrome characterized by increases of the blood flow and/or of the vascular resistance in the portal system. A direct consequence of PHI can appearance different lesions on the gastric mucosa and submucosa, cumulatively termed portal hypertensive gastropathy (PHG). AIMS: To investigate the effects of glutamine on oxidative stress in an experimental model of PHG induced by partial portal vein ligation (PPVL). MATERIAL AND METHODS: Portal pressure, transaminase and alkaline phosphatase activity were quantified. Gastric tissue damage was assessed by histological analysis. Oxidative stress was measured by quantification of cytosolic concentration of thiobarbituric acid reactive substances (TBARS), hydroperoxide-initiated chemiluminescence (QL), and nitric oxide (NO) production. Moreover, activities of the antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were analyzed. RESULTS: Transaminase and alkaline phosphatase activities were not significantly modified by PPVL, indicating absence of liver injury. Histological analysis of gastric sections showed a lost of normal architecture, with edema and vasodilatation. TBARS, QL, and NO production were significantly increased in PPVL animals. A reduction of SOD activity was found. Glutamine administration markedly alleviated histological abnormalities and oxidative stress, normalized SOD activity, and blocked NO overproduction. CONCLUSIONS: Our results confirm that the use of molecules with antioxidant capacity can provide protection of the gastric tissue in portal hypertension. Glutamine treatment can be useful to reduce the oxidative damage induced by PHI on gastric tissue. |
| | |
Authors:
|
Camila Marques; José L Mauriz; Douglas Simonetto; Claudio A Marroni; María J Tuñon; Javier González-Gallego; Norma P Marrón |
Related Documents
:
|
19022665 - Design, synthesis, and biological evaluation of biotin-labeled (-)-ternatin, a potent f... 13789185 - Some biological properties of cephalosporin c and a derivative. 11765035 - Synthesis and analytical evaluation by voltammetric studies of some new indole-3-propio... 20486685 - Synthesis and preliminary biological studies of 3-substituted indoles accessed by a pal... 22061755 - Substitution of nitrite by sorbate and the effect on properties of mortadella. 11667215 - Diastereoselective zwitterionic aza-claisen rearrangement: the synthesis of bicyclic te... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Annals of hepatology Volume: 10 ISSN: 1665-2681 ISO Abbreviation: Ann Hepatol Publication Date: 2011 Oct-Dec |
Date Detail:
|
Created Date: 2011-09-13 Completed Date: 2011-11-23 Revised Date: 2013-05-16 |
Medline Journal Info:
|
Nlm Unique ID: 101155885 Medline TA: Ann Hepatol Country: Mexico |
Other Details:
|
Languages: eng Pagination: 531-9 Citation Subset: IM |
Affiliation:
|
Universidade Federal do Rio Grande do Sul-UFRGS. Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alanine Transaminase
/
blood Alkaline Phosphatase / blood Animals Antioxidants / pharmacology* Aspartate Aminotransferases / blood Biological Markers / blood, metabolism Catalase / metabolism Disease Models, Animal Glutamine / pharmacology* Glutathione Peroxidase / metabolism Hypertension, Portal / complications, drug therapy*, metabolism Ligation Lipid Peroxidation / drug effects Male Nitric Oxide / metabolism Oxidative Stress / drug effects* Portal Vein / surgery Rats Rats, Wistar Stomach / drug effects*, metabolism, pathology Stomach Diseases / etiology, metabolism, pathology, prevention & control* Superoxide Dismutase / metabolism Thiobarbituric Acid Reactive Substances / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Antioxidants; 0/Biological Markers; 0/Thiobarbituric Acid Reactive Substances; 10102-43-9/Nitric Oxide; 56-85-9/Glutamine; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase; EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Alteration of AP-endonuclease1 expression in curcumin-treated fibrotic rats.
Next Document: Protective effect of thymic humoral factor on porcine serum-induced hepatic fibrosis and liver damag...