Document Detail

Glutamine metabolism in children with short-bowel syndrome: a stable isotope study.
MedLine Citation:
PMID:  7970935     Owner:  NLM     Status:  MEDLINE    
Because glutamine is thought to be a major fuel for developing gut, we tested the hypothesis that extensive small-bowel resection alters whole-body glutamine metabolism in vivo. Eleven infants and children who had undergone extensive small intestinal resection (residual bowel length: 35 +/- 13 cm; mean +/- SD) and four control infants received 4-h primed, continuous i.v. infusions of L-[(1-13C]leucine and L-[2-15N]glutamine in the postabsorptive state. The appearance rates of glutamine and leucine into plasma were determined from stable isotope enrichments in plasma at steady state. We observed the following: 1) Regardless of intestinal status, leucine and glutamine fluxes were higher in infants than values previously reported for adults. 2) Small-bowel resection was associated with a reduction in glutamine appearance rate (568 +/- 124 lean body mass-1.h-1 in short-bowel syndrome infants versus 816 +/- 149 lean body mass-1.h-1 in control infants; p < 0.05). 3) In contrast, leucine appearance rate was unaltered in short-bowel syndrome patients. The findings suggest that the small intestine plays a prominent role in glutamine metabolism in human infants.
R Hankard; O Goulet; C Ricour; M Rongier; V Colomb; D Darmaun
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Pediatric research     Volume:  36     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1994-12-07     Completed Date:  1994-12-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  202-6     Citation Subset:  IM    
Service de Gastroentérologie et Nutrition, Hôpital Necker-Enfants-Malades, Paris, France.
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MeSH Terms
Carbon Isotopes
Child, Preschool
Glutamine / metabolism*
Intestine, Small / metabolism
Leucine / metabolism
Nitrogen Isotopes
Short Bowel Syndrome / metabolism*
Reg. No./Substance:
0/Carbon Isotopes; 0/Nitrogen Isotopes; 56-85-9/Glutamine; 61-90-5/Leucine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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