| Glutamine and leucine nitrogen kinetics and their relation to urea nitrogen in newborn infants. | |
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MedLine Citation:
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PMID: 11832365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glutamine kinetics and its relation to transamination of leucine and urea synthesis were quantified in 16 appropriate-for-gestational-age infants, four small-for-gestational-age infants, and seven infants of diabetic mothers. Kinetics were measured between 4 and 5 h after the last feed (fasting) and in response to formula feeding using [5-(15)N]glutamine, [1-(13)C,(15)N]leucine, [(2)H(5)]phenylalanine, and [(15)N(2)]urea tracers. Leucine nitrogen and glutamine kinetics during fasting were significantly higher than those reported in adults. De novo synthesis accounted for approximately 85% of glutamine turnover. In response to formula feeding, a significant increase (P = 0.04) in leucine nitrogen turnover was observed, whereas a significant decrease (P = 0.002) in glutamine and urea rate of appearance was seen. The rate of appearance of leucine nitrogen was positively correlated (r(2) = 0.59, P = 0.001) with glutamine turnover. Glutamine flux was negatively correlated (r(2) = 0.39, P = 0.02) with the rate of urea synthesis. These data suggest that, in the human newborn, glutamine turnover is related to a high anaplerotic flux into the tricarboxylic acid cycle as a consequence of a high rate of protein turnover. The negative relationship between glutamine turnover and the irreversible oxidation of protein (urea synthesis) suggests an important role of glutamine as a nitrogen source for other synthetic processes and accretion of body proteins. |
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Authors:
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Prabhu S Parimi; Srisatish Devapatla; Lourdes Gruca; Alicia M O'Brien; Richard W Hanson; Satish C Kalhan |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of physiology. Endocrinology and metabolism Volume: 282 ISSN: 0193-1849 ISO Abbreviation: Am. J. Physiol. Endocrinol. Metab. Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-02-08 Completed Date: 2002-03-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100901226 Medline TA: Am J Physiol Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: E618-25 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Robert Schwartz M.D. Center for Metabolism and Nutrition, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44109-1998, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Urea Nitrogen* Carbon Isotopes Deuterium Female Glutamine / blood*, diagnostic use Humans Infant, Newborn Infant, Small for Gestational Age Kinetics Leucine / blood*, diagnostic use Nitrogen / blood* Nitrogen Isotopes Phenylalanine / diagnostic use Pregnancy Pregnancy in Diabetics Urea / diagnostic use |
| Grant Support | |
ID/Acronym/Agency:
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DK-07319/DK/NIDDK NIH HHS; HD-11089/HD/NICHD NIH HHS; RR-00080/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Carbon Isotopes; 0/Nitrogen Isotopes; 56-85-9/Glutamine; 57-13-6/Urea; 61-90-5/Leucine; 63-91-2/Phenylalanine; 7727-37-9/Nitrogen; 7782-39-0/Deuterium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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