Document Detail

Glutamine and leucine nitrogen kinetics and their relation to urea nitrogen in newborn infants.
MedLine Citation:
PMID:  11832365     Owner:  NLM     Status:  MEDLINE    
Glutamine kinetics and its relation to transamination of leucine and urea synthesis were quantified in 16 appropriate-for-gestational-age infants, four small-for-gestational-age infants, and seven infants of diabetic mothers. Kinetics were measured between 4 and 5 h after the last feed (fasting) and in response to formula feeding using [5-(15)N]glutamine, [1-(13)C,(15)N]leucine, [(2)H(5)]phenylalanine, and [(15)N(2)]urea tracers. Leucine nitrogen and glutamine kinetics during fasting were significantly higher than those reported in adults. De novo synthesis accounted for approximately 85% of glutamine turnover. In response to formula feeding, a significant increase (P = 0.04) in leucine nitrogen turnover was observed, whereas a significant decrease (P = 0.002) in glutamine and urea rate of appearance was seen. The rate of appearance of leucine nitrogen was positively correlated (r(2) = 0.59, P = 0.001) with glutamine turnover. Glutamine flux was negatively correlated (r(2) = 0.39, P = 0.02) with the rate of urea synthesis. These data suggest that, in the human newborn, glutamine turnover is related to a high anaplerotic flux into the tricarboxylic acid cycle as a consequence of a high rate of protein turnover. The negative relationship between glutamine turnover and the irreversible oxidation of protein (urea synthesis) suggests an important role of glutamine as a nitrogen source for other synthetic processes and accretion of body proteins.
Prabhu S Parimi; Srisatish Devapatla; Lourdes Gruca; Alicia M O'Brien; Richard W Hanson; Satish C Kalhan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of physiology. Endocrinology and metabolism     Volume:  282     ISSN:  0193-1849     ISO Abbreviation:  Am. J. Physiol. Endocrinol. Metab.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-02-08     Completed Date:  2002-03-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100901226     Medline TA:  Am J Physiol Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E618-25     Citation Subset:  IM    
Department of Pediatrics, Robert Schwartz M.D. Center for Metabolism and Nutrition, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44109-1998, USA.
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MeSH Terms
Blood Urea Nitrogen*
Carbon Isotopes
Glutamine / blood*,  diagnostic use
Infant, Newborn
Infant, Small for Gestational Age
Leucine / blood*,  diagnostic use
Nitrogen / blood*
Nitrogen Isotopes
Phenylalanine / diagnostic use
Pregnancy in Diabetics
Urea / diagnostic use
Grant Support
Reg. No./Substance:
0/Carbon Isotopes; 0/Nitrogen Isotopes; 56-85-9/Glutamine; 57-13-6/Urea; 61-90-5/Leucine; 63-91-2/Phenylalanine; 7727-37-9/Nitrogen; 7782-39-0/Deuterium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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