| Glutamine-induced membrane currents in cultured chick spinal cord neurons. | |
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MedLine Citation:
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PMID: 2901704 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of L-glutamine (GLN) on cultured spinal cord neurons from the chick were studied in the whole cell mode of the patch clamp technique. GLN induced membrane currents rectified at positive membrane potentials (m.p.) and reversed polarity close to zero m.p. The dose-response curve was nearly linear at a semilogarithmic scale for concentrations of 10(-5) M-10(-2) M. Summation of the responses evoked by GLN (10(-3) M) and glycine (10(-3) M) was observed when these two amino acids were applied together, while no significant increase of the responses was present when GLN was applied together with L-glutamate (10(-3) M) or kainate (10(-3) M). It is suggested that GLN binds to the glutamate receptors and activates the same type of ionic channels as glutamate and kainate. |
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Authors:
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J Krůsek; L Vyklický; L Vyklický; V Vlachová |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neuroscience letters Volume: 90 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1988 Aug |
Date Detail:
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Created Date: 1988-10-20 Completed Date: 1988-10-20 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 333-7 Citation Subset: IM |
Affiliation:
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Institute of Physiology, Czechoslovak Academy of Sciences, Prague, C.S.S.R. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cells, Cultured Chick Embryo Glutamates / pharmacology Glutamic Acid Glutamine / pharmacology* Glycine / pharmacology Kainic Acid / pharmacology Membrane Potentials / drug effects Receptors, Glutamate Receptors, Neurotransmitter / drug effects, physiology Spinal Cord / drug effects, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Glutamates; 0/Receptors, Glutamate; 0/Receptors, Neurotransmitter; 487-79-6/Kainic Acid; 56-40-6/Glycine; 56-85-9/Glutamine; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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