Document Detail

Glutamine and glutamate as vital metabolites.
MedLine Citation:
PMID:  12563517     Owner:  NLM     Status:  MEDLINE    
Glucose is widely accepted as the primary nutrient for the maintenance and promotion of cell function. This metabolite leads to production of ATP, NADPH and precursors for the synthesis of macromolecules such as nucleic acids and phospholipids. We propose that, in addition to glucose, the 5-carbon amino acids glutamine and glutamate should be considered to be equally important for maintenance and promotion of cell function. The functions of glutamine/glutamate are many, i.e., they are substrates for protein synthesis, anabolic precursors for muscle growth, they regulate acid-base balance in the kidney, they are substrates for ureagenesis in the liver and for hepatic and renal gluconeogenesis, they act as an oxidative fuel for the intestine and cells of the immune system, provide inter-organ nitrogen transport, and act as precursors of neurotransmitter synthesis, of nucleotide and nucleic acid synthesis and of glutathione production. Many of these functions are interrelated with glucose metabolism. The specialized aspects of glutamine/glutamate metabolism of different glutamine-utilizing cells are discussed in the context of glucose requirements and cell function.
P Newsholme; M M R Lima; J Procopio; T C Pithon-Curi; S Q Doi; R B Bazotte; R Curi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2003-01-29
Journal Detail:
Title:  Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]     Volume:  36     ISSN:  0100-879X     ISO Abbreviation:  Braz. J. Med. Biol. Res.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-03     Completed Date:  2003-06-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8112917     Medline TA:  Braz J Med Biol Res     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  153-63     Citation Subset:  IM    
Department of Biochemistry, Conway Institute of Biomolecular and Biomedical Research, University College of Dublin, Belfield, Dublin, Ireland.
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MeSH Terms
Cell Physiological Phenomena*
Glucose / metabolism*,  physiology
Glutamates / metabolism*,  physiology
Glutamine / metabolism*,  physiology
Hydrogen-Ion Concentration
Time Factors
Reg. No./Substance:
0/Glutamates; 50-99-7/Glucose; 56-85-9/Glutamine

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