| Glutamine-fueled mitochondrial metabolism is decoupled from glycolysis in melanoma. | |
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MedLine Citation:
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PMID: 22846158 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In this perspective we revise the historic notion that cancer is a disease of mitochondria. We summarize recent findings on the function and re-wiring of central carbon metabolism in melanoma. Metabolic profiling studies using stable isotope tracers show that glycolysis is decoupled from the tricarboxylic acid (TCA) cycle. This decoupling is not "dysfunction" but rather an alternate wiring required by tumor cells to remain metabolically versatile. In large part, this requirement is met by glutamine feeding the TCA cycle as an alternative source of carbon. Glutamine is also used in non-conventional ways, like traveling in reverse through the TCA flux to feed fatty acid biosynthesis. The biosynthetic networks linked to non-essential amino acids alanine, serine, arginine and proline are also significantly impacted by the use of glutamine as an alternate carbon source. Significance Stable isotope-enhanced research has brought new insights into the basic understanding of metabolism in melanoma, particularly on the role of glutamine-fueled mitochondrial metabolism. Metabolic rewiring affords melanoma a metabolic robustness, flexibility and versatility. Interfering with the rewiring of central carbon metabolism in melanoma is a new therapeutic opportunity. © 2012 John Wiley & Sons A/S. |
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Authors:
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Fabian V Filipp; Boris Ratnikov; Jessica De Ingeniis; Jeffrey W Smith; Andrei L Osterman; David A Scott |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-31 |
Journal Detail:
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Title: Pigment cell & melanoma research Volume: - ISSN: 1755-148X ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101318927 Medline TA: Pigment Cell Melanoma Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 John Wiley & Sons A/S. |
Affiliation:
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University of California Merced, Systems Biology and Cancer Metabolism, 5200 North Lake Rd, Merced, CA 95343 Cancer Research Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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