Document Detail


Glutamine-fueled mitochondrial metabolism is decoupled from glycolysis in melanoma.
MedLine Citation:
PMID:  22846158     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this perspective, we revise the historic notion that cancer is a disease of mitochondria. We summarize recent findings on the function and rewiring of central carbon metabolism in melanoma. Metabolic profiling studies using stable isotope tracers show that glycolysis is decoupled from the tricarboxylic acid (TCA) cycle. This decoupling is not 'dysfunction' but rather an alternate wiring required by tumor cells to remain metabolically versatile. In large part, this requirement is met by glutamine feeding the TCA cycle as an alternative source of carbon. Glutamine is also used in non-conventional ways, like traveling in reverse through the TCA flux to feed fatty acid biosynthesis. Biosynthetic networks linked with non-essential amino acids alanine, serine, arginine, and proline are also significantly impacted by the use of glutamine as an alternate carbon source.
Authors:
Fabian V Filipp; Boris Ratnikov; Jessica De Ingeniis; Jeffrey W Smith; Andrei L Osterman; David A Scott
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-10-01
Journal Detail:
Title:  Pigment cell & melanoma research     Volume:  25     ISSN:  1755-148X     ISO Abbreviation:  Pigment Cell Melanoma Res     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-22     Completed Date:  2013-09-03     Revised Date:  2014-04-16    
Medline Journal Info:
Nlm Unique ID:  101318927     Medline TA:  Pigment Cell Melanoma Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  732-9     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S.
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MeSH Terms
Descriptor/Qualifier:
Citric Acid Cycle
Glutamine / metabolism*
Glycolysis*
Humans
Melanoma / metabolism*
Mitochondria / metabolism*
Skin Neoplasms / metabolism
Grant Support
ID/Acronym/Agency:
CA128814/CA/NCI NIH HHS; CA154887/CA/NCI NIH HHS; P01 CA128814/CA/NCI NIH HHS; P30 CA030199/CA/NCI NIH HHS; R00 CA154887/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0RH81L854J/Glutamine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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